Meng Xiang-Long, Wang Yuan, Wang Hong-Li, Nie Huan-Huan, Cheng Bei-Jing, Cao Hong-Juan, Li Xiu-de, Wang Su-Fang, Chen Gui-Mei, Tao Fang-Biao, Sheng Jie, Yang Lin-Sheng
School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Meishan Road 81, Hefei, 230032, Anhui, China.
Lu'an Municipal Center for Disease Control and Prevention, Lu'an, 237008, Anhui, China.
Environ Sci Pollut Res Int. 2022 Dec;29(60):90351-90363. doi: 10.1007/s11356-022-22066-0. Epub 2022 Jul 22.
The evidence about the association of the essential trace element (ETE) mixture with atherosclerotic cardiovascular disease (ASCVD) amongst older adults is limited. This study aims to evaluate the associations of single ETEs and the ETE mixture with the 10-year ASCVD risks and its predicting factors in Chinese community-dwelling older adults. A total of 607 community-dwelling older adults were included in this study. Blood levels of vanadium (V), chromium (Cr), manganese (Mn), cobalt (Co), nickel (Ni), and selenium (Se) were assessed by inductively coupled plasma mass spectrometry. The predicted 10-year ASCVD risk was calculated using the Prediction for ASCVD Risk in China (China-PAR) equations. Traditional linear regressions and Bayesian kernel machine regression (BKMR) were used to assess the associations of single ETEs and the ETE mixture with the 10-year ASCVD risks and its predicting factors such as systolic blood pressure (SBP), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), diabetes, and waist circumference (WC). In linear regression models, blood Cr levels were negatively associated with the 10-year ASCVD risks after adjustment for covariates (β = - 0.07, 95% CI = - 0.11 ~ - 0.03); The 3th quartile (Q3) of Se levels was also associated with a lower 10-year ASCVD risks when compared with the lowest quartile (Q1) of Se levels (β vs. : - 0.12, 95% CI = - 0.22 ~ - 0.02). In BKMR models, the negative associations of Cr and Se with the 10-year ASCVD risks were observed. Higher blood levels of ETE mixture were associated with decreased 10-year ASCVD risks in a dose-response pattern, with Cr having the highest value of the posterior inclusion probability (PIP) within the mixture. Furthermore, a positive association between Cr and HDL-C and a negative association between Se and SBP were found in both linear regression and BKMR models. Cr and Se were negatively associated with the 10-year ASCVD risks, individually and as a mixture. ETE mixture showed a linear dose-response association with decreased 10-year ASCVD risks, with Cr being the most important component within the mixture. The negative association of the ETE mixture with the 10-year ASCVD risks may be attributed to Cr and Se, mainly mediated by HDL-C and SBP, respectively. Further cohort studies are needed to clarify this association.
关于必需微量元素（ETE）混合物与老年人动脉粥样硬化性心血管疾病（ASCVD）之间关联的证据有限。本研究旨在评估中国社区居住老年人中单一ETE和ETE混合物与10年ASCVD风险及其预测因素之间的关联。本研究共纳入607名社区居住老年人。采用电感耦合等离子体质谱法评估钒（V）、铬（Cr）、锰（Mn）、钴（Co）、镍（Ni）和硒（Se）的血药浓度。使用中国ASCVD风险预测（China-PAR）方程计算预测的10年ASCVD风险。采用传统线性回归和贝叶斯核机器回归（BKMR）评估单一ETE和ETE混合物与10年ASCVD风险及其预测因素（如收缩压（SBP）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、糖尿病和腰围（WC））之间的关联。在线性回归模型中，校正协变量后，血Cr水平与10年ASCVD风险呈负相关（β = -0.07，95%CI = -0.11 ~ -0.03）；与Se水平的最低四分位数（Q1）相比，Se水平的第3四分位数（Q3）也与较低的10年ASCVD风险相关（β对比：-0.12，95%CI = -0.22 ~ -0.02）。在BKMR模型中，观察到Cr和Se与10年ASCVD风险呈负相关。ETE混合物血药浓度升高与10年ASCVD风险降低呈剂量反应模式相关，混合物中Cr的后验包含概率（PIP）值最高。此外，在线性回归和BKMR模型中均发现Cr与HDL-C呈正相关，Se与SBP呈负相关。Cr和Se分别单独及作为混合物与10年ASCVD风险呈负相关。ETE混合物与10年ASCVD风险呈线性剂量反应关联，且风险降低，其中Cr是混合物中最重要的成分。ETE混合物与10年ASCVD风险的负相关可能归因于Cr和Se，主要分别由HDL-C和SBP介导。需要进一步的队列研究来阐明这种关联。
