Du Guihua, Song Xiaoguang, Zhou Fankun, Ouyang Lu, Li Qi, Ruan Shiying, Su Rui, Rao Shaoqi, Zhu Yanhui, Xie Jie, Feng Chang, Fan Guangqin
Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang, 330006, People's Republic of China.
Jiangxi Provincial Key Laboratory of Preventive Medicine, Nanchang University, Nanchang, 330006, People's Republic of China.
Biol Trace Elem Res. 2024 Aug;202(8):3483-3495. doi: 10.1007/s12011-023-03951-2. Epub 2023 Nov 22.
Exposure to essential and toxic metals occurs simultaneously as a mixture in real-life. However, there is no consensus regarding the effects of co-exposure to multiple metal(loid)s (designated hereafter metals) on blood lipid levels. Thus, blood concentrations of six human essential metals and five toxic metals in 720 general populations from southeastern China were simultaneously determined as a measure of exposure. In addition, quantile g-computation, Bayesian kernel machine regression, elastic net regression, and generalized linear model were used to investigate both the joint and individual effects of exposure to this metal mixture on human blood lipid levels. The significant positive joint effect of exposure to this metal mixture on serum total cholesterol (TC) levels, rather than on serum triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, Castelli risk index I, Castelli risk index II, atherogenic coefficient, and non-HDL-C levels, was found. In addition, the positive effect may be primarily driven by selenium (Se), lead (Pb), and mercury (Hg) exposure. In addition, on the effect of TC levels, the synergistic effect between Pb and Hg and the antagonistic effect between Se and Pb were identified. Our finding suggests that combined exposure to this metal mixture may affect human blood lipid levels. Therefore, reducing exposure to heavy metals, such as Pb and Hg, should be a priority for the general population. In addition, Se supplementation should also be considered with caution.
在现实生活中，人体会同时接触到必需金属和有毒金属的混合物。然而，对于多种金属（以下简称金属）共同暴露对血脂水平的影响，目前尚无定论。因此，我们同时测定了来自中国东南部的720名普通人群中六种人体必需金属和五种有毒金属的血液浓度，以此作为暴露量的衡量指标。此外，我们还使用了分位数g计算、贝叶斯核机器回归、弹性网络回归和广义线性模型，来研究这种金属混合物暴露对人体血脂水平的联合效应和个体效应。结果发现，这种金属混合物暴露对血清总胆固醇（TC）水平有显著的正向联合效应，而对血清甘油三酯、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇、卡斯泰利风险指数I、卡斯泰利风险指数II、致动脉粥样硬化系数和非HDL-C水平没有影响。此外，这种正向效应可能主要由硒（Se）、铅（Pb）和汞（Hg）的暴露驱动。此外，在对TC水平的影响方面，我们还发现了Pb和Hg之间的协同效应以及Se和Pb之间的拮抗效应。我们的研究结果表明，同时暴露于这种金属混合物可能会影响人体血脂水平。因此，减少铅和汞等重金属的暴露，应成为普通人群的首要任务。此外，补充硒也应谨慎考虑。
