Kuz'min S N, Belaia Iu A
Zh Mikrobiol Epidemiol Immunobiol. 1978 Apr(4):59-62.
The authors determined the immunoglobulin and specific antibodies level in the blood serum of 17 children aged from 7 to 10 years during the immunization with live dysentery Some vaccine. Mancini's test demonstrated the absence of any differences in the amount of IgA and IgG in children of the given age group and in adults before the immunization; in comparison with adults, IgM was increased in children. 14 to 20 days after the immunization in children there was a significant elevation of the IgG only, whereas in adults the immunoglobulin level of all the 3 classes increased significantly. The titres of specific antibodies of the IgA-, IgG-classes and of hemagglutinins before the immunization detected by Coombs' test failed to differ in children from the titres of antibodies of these classes in adults; the level of IgM antibodies was much greater in children than in adults. The changes and accumulation of antibodies of various classes in children and adults during the enteral immunization with live dysentery vaccine differed significantly: in children the vaccine stimulated the IgA- and the IgM-antibody synthesis, whereas adults responded to the immunization by increased production of all the 3 antibody classes. On the basis of the noted immunological shifts a conclusions was drawn on a marked local immunization activity of the live enteral Sonne dysentery vaccine from the spontaneous mutant in children.
作者测定了17名7至10岁儿童在接种痢疾活菌疫苗期间血清中的免疫球蛋白和特异性抗体水平。 Mancini试验表明,在该年龄组儿童和免疫前的成年人中,IgA和IgG的量没有任何差异;与成年人相比,儿童的IgM增加。儿童免疫后14至20天,仅IgG显著升高,而成年人所有3类免疫球蛋白水平均显著升高。通过库姆斯试验检测,免疫前儿童IgA、IgG类特异性抗体和血凝素的滴度与成年人这些类别的抗体滴度没有差异;儿童的IgM抗体水平比成年人高得多。在口服痢疾活菌疫苗免疫期间,儿童和成年人各类抗体的变化和积累有显著差异:在儿童中,疫苗刺激IgA和IgM抗体合成,而成年人对免疫的反应是所有3类抗体的产生增加。根据所观察到的免疫变化,得出结论:儿童中来自自发突变体的口服宋内痢疾活菌疫苗具有显著的局部免疫活性。