Kuz'min S N, Belaia Iu A, Birkovskiĭ Iu E, Milovanova L P, Pavlova L I
Zh Mikrobiol Epidemiol Immunobiol. 1978 Sep(9):47-52.
The authors studied the immunological shifts in the blood and saliva of 357 adults immunized with live enteral dysentery Sonne vaccine from a spontaneous mutant according to different schemes (1, 2, 3, 4 injections at 2--3-day intervals. The general level of IgA, IgG, and IgM increased during the immunization; there was also an elevation of the specific antibodies level of these classes in the blood of the persons vaccinated. Accretion was the greatest of IgA both in the blood and in saliva of the immunized persons; this pointed to a marked, chiefly local, immunological activity of the vaccine. As shown, during the immunization the rise and the changes in the antibody level of various immunoglobulin classes differed from such in dysentery infection; in the latter case, along with the IgA-antibodies there was a marked elevation of the IgG- and IgM-antibodies level. It is supposed that there was a possibility of a changed of a 4-time immunization scheme to-3-time one, with increase of intervals between the vaccine administration.
作者研究了357名按照不同方案(间隔2至3天注射1、2、3、4次)接种了来自自发突变体的活肠痢疾宋内疫苗的成年人血液和唾液中的免疫变化。免疫期间IgA、IgG和IgM的总体水平升高;接种疫苗者血液中这些类别的特异性抗体水平也有所升高。免疫者血液和唾液中IgA的增加最为显著;这表明该疫苗具有显著的、主要是局部的免疫活性。结果显示,免疫期间各种免疫球蛋白类别的抗体水平的升高和变化与痢疾感染时不同;在后一种情况下,除了IgA抗体外,IgG和IgM抗体水平也显著升高。据推测,有可能将4次免疫方案改为3次免疫方案,同时增加疫苗接种间隔时间。