Hubei Province Wuhan DongXihu District Maternal and Child Health Hospital, Wuhan, Hubei430040, China..
Cell Mol Biol (Noisy-le-grand). 2022 Feb 28;68(2):208-212. doi: 10.14715/cmb/2022.68.2.30.
The current research was carried out to explore the role and mechanism of IL - 17 and its gene polymorphisms in dyslipidemia caused by obstructive sleep apnea syndrome in children. For this aim, a total of 86 children with obstructive sleep apnea syndrome admitted to our hospital from January 2018 to January 2020 were selected as the study subjects, and the lipid-related indexes of the children were detected by a fully automatic biochemical analyzer, and they were divided into OSAHS group (54 cases), combined dyslipidemia group (32 cases), and another 40 healthy children who underwent physical examination in our hospital during the same period were selected as the healthy group. Levels of IL-7 and AHI, FEV1 / FVC were analyzed in each group, and levels of TC, TG, and LDL-C were compared to observe different sites of IL-17, namely IL-17A (rs3748067; The loci of IL-17F (rs763780, rs2397084) were genotyped in different groups to analyze the association between IL-17 and dyslipidemia in children with OSAHS. Results showed that higher IL-7 and AHI levels and lower FEV1 / FVC levels were found in the combined dyslipidemia and OSAHS groups compared with the healthy group, and higher IL-7 and AHI levels and lower FEV1 / FVC levels were found in the combined dyslipidemia group compared with the OSAHS group (P < 0.05); TC, TG and LDL-C level expression were higher in the combined dyslipidemia and OSAHS groups compared with the healthy group, and TC, TG and LDL-C level expression were higher in the combined dyslipidemia group compared with the OSAHS group (P < 0.05). IL-17 was positively correlated with TC, TG and LDL-C. It was concluded that in the development of OSAHS, IL-7 levels are significantly expressed, at the same time OSAHS children progress dyslipidemia, which has some correlation with IL-17, and IL-17 gene polymorphism, IL-17A (rs3748067); All were significantly expressed in the IL-17F (rs763780, rs2397084) locus.
本研究旨在探讨白细胞介素-17（IL-17）及其基因多态性在儿童阻塞性睡眠呼吸暂停综合征（OSAHS）引起的血脂异常中的作用及机制。为此，选取 2018 年 1 月至 2020 年 1 月我院收治的 OSAHS 患儿 86 例为研究对象，采用全自动生化分析仪检测患儿的血脂相关指标，根据检测结果将患儿分为 OSAHS 组（54 例）、合并血脂异常组（32 例），另选取同期我院体检的健康儿童 40 例作为健康组。分析各组 IL-7 及 AHI、FEV1/FVC 水平，比较各组 TC、TG、LDL-C 水平，观察 IL-17 不同作用部位，即 IL-17A(rs3748067)；IL-17F(rs763780、rs2397084)基因座的基因型，分析 IL-17 与 OSAHS 儿童血脂异常的关系。结果显示，合并血脂异常组及 OSAHS 组患儿的 IL-7 及 AHI 水平高于健康组，FEV1/FVC 水平低于健康组，合并血脂异常组患儿的 IL-7 及 AHI 水平高于 OSAHS 组，FEV1/FVC 水平低于 OSAHS 组（P＜0.05）；合并血脂异常组及 OSAHS 组患儿的 TC、TG、LDL-C 水平表达高于健康组，合并血脂异常组患儿的 TC、TG、LDL-C 水平表达高于 OSAHS 组（P＜0.05）。IL-17 与 TC、TG、LDL-C 呈正相关。结论：在 OSAHS 的发生发展中，IL-7 水平有明显表达，同时 OSAHS 患儿发生血脂异常，与 IL-17 有一定相关性，且 IL-17 基因多态性、IL-17A(rs3748067)；IL-17F(rs763780、rs2397084)基因座均有明显表达。
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