Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal, Madhya Pradesh, India.
Synapse. 2022 Sep;76(11-12):e22248. doi: 10.1002/syn.22248. Epub 2022 Jul 29.
Several proteins contain signaling domains that can regulate the cell membrane dynamics as well as the underlying cytoskeleton. Among these, Bin-Amphiphysin-Rvs (BAR) domain-containing proteins, with their membrane deforming properties, have emerged as the key players in regulating neuronal morphology and inducing neuronal signaling that can modulate synaptic architecture. While the biochemical and structural basis of membrane deformation by the BAR-domain proteins has been extensively studied, the in vivo contexts in which these proteins function remain to be elucidated. Despite the discovery of BAR-domain proteins over 25 years ago, most of the studies have primarily focused on understanding the structural and biochemical properties and cell biological processes regulated by these proteins. Understanding the functional requirements of these proteins at the level of multicellular organisms and the way these proteins regulate biological processes remains a topic of intensive study. In this review, we discuss the functional roles of BAR-domain proteins in the context of membrane dynamics and cellular signaling. We highlight recent developments describing the functional role of these proteins in neuronal morphogenesis, synaptic function, and disease.
几种蛋白质包含信号域，可调节细胞膜动力学和基础细胞骨架。在这些蛋白质中，具有膜变形特性的 Bin-Amphiphysin-Rvs（BAR）结构域蛋白已成为调节神经元形态和诱导神经元信号的关键因子，这些信号可以调节突触结构。虽然 BAR 结构域蛋白介导的膜变形的生化和结构基础已经得到了广泛的研究，但这些蛋白在体内发挥作用的背景仍有待阐明。尽管 BAR 结构域蛋白的发现已经超过 25 年，但大多数研究主要集中在理解这些蛋白的结构和生化特性以及受这些蛋白调控的细胞生物学过程。在多细胞生物水平上理解这些蛋白的功能要求以及这些蛋白调节生物过程的方式仍然是一个深入研究的课题。在这篇综述中，我们讨论了 BAR 结构域蛋白在膜动力学和细胞信号转导方面的功能作用。我们强调了描述这些蛋白在神经元形态发生、突触功能和疾病中的功能作用的最新进展。
