膜塑形由 Bin/ amphiphysin/Rvs (BAR) 结构域蛋白超家族介导。
Membrane shaping by the Bin/amphiphysin/Rvs (BAR) domain protein superfamily.
机构信息
Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 6, 14195 Berlin, Germany.
出版信息
Cell Mol Life Sci. 2011 Dec;68(24):3983-93. doi: 10.1007/s00018-011-0768-5. Epub 2011 Jul 17.
Abstract
BAR domain superfamily proteins have emerged as central regulators of dynamic membrane remodeling, thereby playing important roles in a wide variety of cellular processes, such as organelle biogenesis, cell division, cell migration, secretion, and endocytosis. Here, we review the mechanistic and structural basis for the membrane curvature-sensing and deforming properties of BAR domain superfamily proteins. Moreover, we summarize the present state of knowledge with respect to their regulation by autoinhibitory mechanisms or posttranslational modifications, and their interactions with other proteins, in particular with GTPases, and with membrane lipids. We postulate that BAR superfamily proteins act as membrane-deforming scaffolds that spatiotemporally orchestrate membrane remodeling.
摘要
BAR 结构域超家族蛋白已成为动态膜重塑的核心调控因子，从而在多种细胞过程中发挥重要作用，如细胞器发生、细胞分裂、细胞迁移、分泌和内吞。在此，我们综述 BAR 结构域超家族蛋白感知和变形膜曲率的机制和结构基础。此外，我们总结了目前关于它们受自动抑制机制或翻译后修饰调控的知识状态，以及它们与其他蛋白质，特别是与 GTPases 和膜脂的相互作用。我们假设 BAR 超家族蛋白作为膜变形支架，空间和时间上协调膜重塑。
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