Nawrocka Zofia Anna, Nawrocka Zofia, Nawrocki Jerzy
Ophthalmic Clinic "Jasne Blonia", Rojna 90, Lodz, Poland.
Graefes Arch Clin Exp Ophthalmol. 2023 Jan;261(1):67-76. doi: 10.1007/s00417-022-05774-8. Epub 2022 Jul 23.
The aim of this study was to compare the results of vitrectomy performed in patients' worse eyes with diabetic macular edema to the results of continuous anti-VEGF treatment performed in patients' fellow eyes.
A retrospective interventional study of 14 patients with diabetic macular edema in both eyes. The better eye was always qualified for aflibercept injections (group 1), and the worse eye was scheduled for vitrectomy (group 2). The follow-up lasted 12 months. The following parameters were measured: visual acuity (V), central retinal thickness (CRT), maximum retinal thickness (MRT), central choroidal thickness (CCT), superficial fovea avascular zone (sFAZ) and deep fovea avascular zone (dFAZ), and vessel density at the level of superficial (sVD) and deep (dVD) retinal vessels.
None of the analyzed factors differed between groups with statistical significance at any timepoint. The time of recovery of vision was identical in both eyes (F = 0.91, p = 0.449). The final sFAZ was significantly smaller for group 2 (median 196 μm) than for group 1 (median 375 μm; U = 101.0; p = 0.022; r = 0.44).
Both techniques resulted in similar improvements in visual acuity and decreases in CRT after 1 year. sFAZ decreased in all eyes, with a higher extent after vitrectomy.
本研究旨在比较糖尿病性黄斑水肿患者较差眼行玻璃体切除术的结果与对侧眼行连续抗血管内皮生长因子（VEGF）治疗的结果。
对14例双眼患有糖尿病性黄斑水肿的患者进行回顾性干预研究。较好眼总是符合阿柏西普注射条件（第1组），较差眼则安排行玻璃体切除术（第2组）。随访持续12个月。测量以下参数：视力（V）、视网膜中央厚度（CRT）、视网膜最大厚度（MRT）、脉络膜中央厚度（CCT）、浅表性黄斑无血管区（sFAZ）和深部黄斑无血管区（dFAZ），以及浅表（sVD）和深部（dVD）视网膜血管水平的血管密度。
在任何时间点，两组之间分析的因素均无统计学差异。双眼视力恢复时间相同（F = 0.91，p = 0.449）。第2组的最终sFAZ（中位数196μm）明显小于第1组（中位数375μm；U = 101.0；p = 0.022；r = 0.44）。
两种技术在1年后均导致视力有相似改善且CRT降低。所有眼的sFAZ均减小，玻璃体切除术后减小程度更高。
