Golestan University of Medical Sciences, Gorgan, Iran.
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Pediatr Surg Int. 2022 Sep;38(9):1177-1186. doi: 10.1007/s00383-022-05179-y. Epub 2022 Jul 23.
Liver transplantation is a life-saving treatment for children who are in liver failure. The survival rate index is used to assess the success rate of liver transplantation. The study aimed to assess the survival rate of liver transplantation in children. We searched 5 international databases in this study, including Medline/PubMed, ProQuest, Scopus, Web of Knowledge, and Google Scholar, for published articles by the end of 2020. Also, meta-regression analysis was performed based on the year of the study, and subgroup analysis was performed according to continents. A total of 425 titles were reviewed. Based on the results, 96 articles were entered in the meta-analysis. Established on the random-effect model, the survival rates of 1, 3, 5, and 10 years of transplantation were 86.62%, 77.74%, 73.95%, and 68.60%, respectively. Also, based on the meta-regression results, there was a relationship between the year of the study and the survival rate, as the study year gets more recent, the survival rate is increased. This study can provide documented and comprehensive evidence which can be the basis of many policies and decisions in various sectors of health development, including evaluating treatment options and health interventions in transplantation.
肝移植是治疗肝功能衰竭儿童的救命疗法。生存率指数用于评估肝移植的成功率。本研究旨在评估儿童肝移植的生存率。我们在这项研究中搜索了 5 个国际数据库，包括 Medline/PubMed、ProQuest、Scopus、Web of Knowledge 和 Google Scholar，以获取截至 2020 年底发表的文章。此外，还根据研究年份进行了荟萃回归分析，并根据大洲进行了亚组分析。共审查了 425 个标题。根据结果，有 96 篇文章进入荟萃分析。基于随机效应模型，移植后 1、3、5 和 10 年的生存率分别为 86.62%、77.74%、73.95%和 68.60%。此外，根据荟萃回归结果，研究年份与生存率之间存在关系，随着研究年份的推移，生存率呈上升趋势。本研究可以提供有文件记录和全面的证据，作为许多政策和决策的基础，包括评估治疗方案和移植中的卫生干预措施。
