Guo Fuping, Ma Xudong, Shan Qijun, Zhang Yuelun, Gao Sifa, Chen Jieqin, Chen Yujie, Liu Dawei, Li Taisheng, Zhang Feng, Zhou Xiang
Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
Department of Medical Administration, National Health Commission of the People's Republic of China, Beijing 100044, China.
iScience. 2024 Nov 19;27(12):111420. doi: 10.1016/j.isci.2024.111420. eCollection 2024 Dec 20.
There is limited statistical data on severe hepatitis among hospitalized children in China at a national level. This nationwide study analyzed data from 34,410 children hospitalized for severe hepatitis in mainland China from 2016 to 2022. The overall in-hospital mortality rate was 6.1%. Viral hepatitis accounted for 14.9% of cases, with hepatitis B being the most prevalent. Indeterminate etiology, present in 79.0% of cases, was an independent risk factor for mortality. Findings emphasize the need for enhanced diagnostic methods and targeted interventions for children with severe hepatitis of unknown cause and suggest focused hepatitis B monitoring in older children to improve outcomes. Establishing a dedicated surveillance system is crucial for improving the prognosis of children at high risk for in-hospital mortality due to severe hepatitis.
在中国，全国范围内关于住院儿童重症肝炎的统计数据有限。这项全国性研究分析了2016年至2022年中国大陆34410例因重症肝炎住院儿童的数据。总体住院死亡率为6.1%。病毒性肝炎占病例的14.9%，其中乙型肝炎最为常见。病因不明的情况占79.0%的病例，是死亡的独立危险因素。研究结果强调，对于病因不明的重症肝炎患儿，需要加强诊断方法和针对性干预措施，并建议对大龄儿童进行重点乙型肝炎监测以改善预后。建立专门的监测系统对于改善因重症肝炎导致住院死亡高风险儿童的预后至关重要。
