Ko Kwang Jin, Lim Jihyun, Yu Jiwoong, Kang Danbee, Cho Juhee, Lee Kyu-Sung
Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.
Center for Clinical Epidemiology, Samsung Medical Center, Seoul, Republic of Korea.
Qual Life Res. 2022 Nov;31(11):3221-3228. doi: 10.1007/s11136-022-03183-2. Epub 2022 Jul 23.
Interstitial cystitis/bladder pain syndrome (IC/BPS) has a negative impact on quality of life. We compared health-related quality of life (HRQoL) of patients with IC/BPS with patients having other diseases using the EuroQol five-dimension (EQ-5D) and evaluated whether the HRQoL is improved after surgery.
We compared EQ-5D of patients with Hunner lesion type IC/BPS with patients who had other diseases that cause chronic and severe pain including arthritis and cancer from a cross-sectional analysis of responses to the 2012-2016 Korea National Health and Nutrition Examination Survey. Changes in EQ-5D after transurethral coagulation (TUC) or resection (TUR) were measured in the IC/BPS participants.
Compared to the EQ-5D index of normal population, patients with arthritis, cancer and IC/BPS had - 0.07 (95% CI - 0.07, - 0.06), - 0.01 (95% CI - 0.02, - 0.01), and - 0.21 (95% CI - 0.23, - 0.20) lower scores, respectively. Patients with IC/BPS were 35.9, 9.24, and 9.05 times more likely to have "extreme problem" in pain/discomfort, anxiety/depression, and usual activities EQ-5D domains, respectively, than patients without arthritis/cancer. After TUC or TUR, EQ-5D index was 0.90 in the TUC group and 0.92 in the TUR group.
IC/BPS patients have worse HRQoL than healthy individuals. However, after surgical treatment, HRQoL is restored to a level close to normal.
间质性膀胱炎/膀胱疼痛综合征（IC/BPS）对生活质量有负面影响。我们使用欧洲五维健康量表（EQ-5D）比较了IC/BPS患者与其他疾病患者的健康相关生活质量（HRQoL），并评估了手术后HRQoL是否得到改善。
我们通过对2012 - 2016年韩国国家健康与营养检查调查的回应进行横断面分析，比较了Hunner病变型IC/BPS患者与患有其他导致慢性和严重疼痛疾病（包括关节炎和癌症）患者的EQ-5D。测量了IC/BPS参与者经尿道电凝术（TUC）或切除术（TUR）后EQ-5D的变化。
与正常人群的EQ-5D指数相比，关节炎、癌症和IC/BPS患者的得分分别低 -0.07（95%可信区间 -0.07，-0.06）、-0.01（95%可信区间 -0.02，-0.01）和 -0.21（95%可信区间 -0.23，-0.20）。与没有关节炎/癌症的患者相比，IC/BPS患者在疼痛/不适、焦虑/抑郁和日常活动EQ-5D领域出现“极端问题”的可能性分别高35.9倍、9.24倍和9.05倍。TUC或TUR后，TUC组的EQ-5D指数为0.90，TUR组为0.92。
IC/BPS患者的HRQoL比健康个体差。然而，手术治疗后，HRQoL恢复到接近正常的水平。
