自身免疫性疾病对口腔鳞状细胞癌预后的影响。
Prognostic impact of autoimmune disease in oral cavity squamous cell carcinoma.
机构信息
Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
出版信息
J Surg Oncol. 2022 Dec;126(7):1183-1190. doi: 10.1002/jso.27017. Epub 2022 Jul 23.
BACKGROUND AND OBJECTIVES
Recent literature has highlighted the role of the host in the prognosis of oral squamous cell carcinoma (OSCC). In this study, we retrospectively examined the impact of autoimmune (AI) disorders as an aspect of the host status on survival outcomes in OSCC patients.
METHODS
From a departmental database of OSCC patients (n = 1369), 123 patients with an AI disorder were identified. AI and no-AI groups were compared for survival outcomes.
RESULTS
There were no significant differences in survival between groups for overall survival, disease-specific survival, local, regional, and distant recurrence-free probabilities. However, survival and recurrence-free probabilities were poorer in the AI group versus the no AI group.
CONCLUSION
Patients with AI disease trended towards worse outcomes. This suggests immune dysregulation in these patients may impact oncologic outcomes.
背景与目的
最近的文献强调了宿主在口腔鳞状细胞癌（OSCC）预后中的作用。在这项研究中，我们回顾性地检查了自身免疫（AI）疾病作为宿主状态的一个方面对 OSCC 患者生存结果的影响。
方法
从 OSCC 患者的一个科室数据库（n=1369）中，确定了 123 例患有 AI 疾病的患者。比较 AI 组和非 AI 组的生存结果。
结果
两组在总生存、疾病特异性生存、局部、区域和远处无复发生存率方面无显著差异。然而，AI 组的生存和无复发生存率比非 AI 组差。
结论
患有 AI 疾病的患者倾向于预后更差。这表明这些患者的免疫失调可能影响肿瘤学结果。
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