Department of Regenerative Medicine & Cell Biology, Medical University of South Carolina.
Department of Regenerative Medicine & Cell Biology, Medical University of South Carolina.
Curr Opin Cell Biol. 2022 Aug;77:102117. doi: 10.1016/j.ceb.2022.102117. Epub 2022 Jul 20.
Myosins are a class of motors that participate in a wide variety of cellular functions including organelle transport, cell adhesion, endocytosis and exocytosis, movement of RNA, and cell motility. Among the emerging roles for myosins is regulation of the assembly, morphology, and function of actin protrusions such as microvilli. The intestine harbors an elaborate apical membrane composed of highly organized microvilli. Microvilli assembly and function are intricately tied to several myosins including Myosin 1a, non-muscle Myosin 2c, Myosin 5b, Myosin 6, and Myosin 7b. Here, we review the research progress made in our understanding of myosin mediated apical assembly.
肌球蛋白是一类参与多种细胞功能的分子马达，包括细胞器运输、细胞黏附、内吞作用和外排作用、RNA 运动以及细胞运动。肌球蛋白的新兴作用之一是调节肌动蛋白突起（如微绒毛）的组装、形态和功能。肠道拥有由高度组织化的微绒毛组成的精细顶端膜。微绒毛的组装和功能与几种肌球蛋白密切相关，包括肌球蛋白 1a、非肌肉肌球蛋白 2c、肌球蛋白 5b、肌球蛋白 6 和肌球蛋白 7b。在这里，我们回顾了我们在理解肌球蛋白介导的顶端组装方面所取得的研究进展。
