牙周炎中的骨免疫学：Th17/IL-17 炎症性骨丢失的范例。
Osteoimmunology in periodontitis; a paradigm for Th17/IL-17 inflammatory bone loss.
机构信息
Oral Immunity and Infection Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 9000 Rockville Pike, 30 convent Dr, Bldg30, Room 327, Bethesda, MD 20892, United States of America.
出版信息
Bone. 2022 Oct;163:116500. doi: 10.1016/j.bone.2022.116500. Epub 2022 Jul 20.
Abstract
Periodontitis is a prevalent human disease of inflammation-induced bone destruction. Through studies in patient lesions of rare and common forms of periodontitis and animal model experimentation, Th17/IL-17 related immune pathways have emerged as mediators of disease pathology. In this focused review, we examine mechanisms of induction, amplification and pathogenicity of Th17 cells in periodontitis.
摘要
牙周炎是一种普遍的人类炎症性骨破坏疾病。通过对罕见和常见形式的牙周炎患者病变以及动物模型实验的研究，Th17/IL-17 相关免疫途径已成为疾病病理的介质。在本专题综述中，我们研究了牙周炎中 Th17 细胞的诱导、扩增和致病性的机制。
相似文献
1
Osteoimmunology in periodontitis; a paradigm for Th17/IL-17 inflammatory bone loss.牙周炎中的骨免疫学：Th17/IL-17 炎症性骨丢失的范例。
Bone. 2022 Oct;163:116500. doi: 10.1016/j.bone.2022.116500. Epub 2022 Jul 20.
2
The presence, function and regulation of IL-17 and Th17 cells in periodontitis.白细胞介素-17及辅助性T细胞17在牙周炎中的存在、功能及调控
J Clin Periodontol. 2014 Jun;41(6):541-9. doi: 10.1111/jcpe.12238. Epub 2014 Apr 15.
3
Complement Is Required for Microbe-Driven Induction of Th17 and Periodontitis.补体对于微生物驱动的 Th17 诱导和牙周炎是必需的。
J Immunol. 2022 Oct 1;209(7):1370-1378. doi: 10.4049/jimmunol.2200338. Epub 2022 Aug 26.
4
Mucosal Langerhans Cells Promote Differentiation of Th17 Cells in a Murine Model of Periodontitis but Are Not Required for Porphyromonas gingivalis-Driven Alveolar Bone Destruction.黏膜朗格汉斯细胞在牙周炎小鼠模型中促进Th17细胞分化，但不是牙龈卟啉单胞菌驱动的牙槽骨破坏所必需的。
J Immunol. 2016 Aug 15;197(4):1435-46. doi: 10.4049/jimmunol.1502693. Epub 2016 Jul 11.
5
[Research progress in secreting sytokines interferon-gamma and interleukin-17 of T helper 1 and 17 cells on periodontitis].辅助性T细胞1和17细胞分泌细胞因子γ干扰素和白细胞介素-17在牙周炎中的研究进展
Zhonghua Kou Qiang Yi Xue Za Zhi. 2019 Jun 9;54(6):420-424. doi: 10.3760/cma.j.issn.1002-0098.2019.06.015.
6
[Effects of T helper 1 cells and T helper 17 cells secreting cytokines on rat models of experimental periodontitis].[分泌细胞因子的辅助性T1细胞和辅助性T17细胞对实验性牙周炎大鼠模型的影响]
Zhonghua Kou Qiang Yi Xue Za Zhi. 2017 Dec 9;52(12):740-747. doi: 10.3760/cma.j.issn.1002-0098.2017.12.006.
7
T Helper 17 Cells as Pathogenic Drivers of Periodontitis.辅助性 T 细胞 17 作为牙周炎的致病驱动因素。
Adv Exp Med Biol. 2019;1197:107-117. doi: 10.1007/978-3-030-28524-1_9.
8
Th17-to-Tfh plasticity during periodontitis limits disease pathology.牙周炎发病过程中 Th17 向 Tfh 的可塑性受限。
J Exp Med. 2024 Aug 5;221(8). doi: 10.1084/jem.20232015. Epub 2024 May 31.
9
The mouse experimental periodontitis by silk-ligature placement triggers systemic inflammation potentially exacerbating pulmonary inflammation.通过丝线结扎诱导的小鼠实验性牙周炎会引发全身炎症，可能会加重肺部炎症。
Biomed Res. 2025;46(2):61-76. doi: 10.2220/biomedres.46.61.
10
CD8 Foxp3 T Cells Affect Alveolar Bone Homeostasis via Modulating Tregs/Th17 During Induced Periodontitis: an Adoptive Transfer Experiment.CD8 Foxp3+T 细胞通过调节诱导性牙周炎中的 Tregs/Th17 影响牙槽骨稳态：一项过继转移实验。
Inflammation. 2018 Oct;41(5):1791-1803. doi: 10.1007/s10753-018-0822-7.
引用本文的文献
1
Genistein in the Prevention and Treatment of Periodontitis: A Review.染料木黄酮在牙周炎防治中的研究综述
Food Sci Nutr. 2025 Aug 4;13(8):e70657. doi: 10.1002/fsn3.70657. eCollection 2025 Aug.
2
The Role of Interleukin-23 and Interleukin-17 in Peri-Implant Crevicular Fluid of Subjects With Peri-Implant Disease: A Systematic Review.白细胞介素-23和白细胞介素-17在种植体周围疾病患者种植体周围龈沟液中的作用：一项系统评价
J Clin Lab Anal. 2025 Jun 22:e70071. doi: 10.1002/jcla.70071.
3
Effect of Adiponectin on the Expression of Selected Cytokines in Periodontal Ligament Cells.脂联素对牙周膜细胞中特定细胞因子表达的影响。
Biology (Basel). 2025 Mar 21;14(4):321. doi: 10.3390/biology14040321.
4
Efficacy of Oral Intake of Hydrogen-Rich Jelly Intake on Gingival Inflammation: A Double-Blind, Placebo-Controlled and Exploratory Randomized Clinical Trial.口服富氢果冻对牙龈炎症的疗效：一项双盲、安慰剂对照的探索性随机临床试验。
Healthcare (Basel). 2025 Mar 6;13(5):577. doi: 10.3390/healthcare13050577.
5
Rapid and relaying deleterious effects of a gastrointestinal pathogen, , on bone, an extra-intestinal organ.一种胃肠道病原体对骨（一种肠外器官）产生的快速且转移性有害影响。
iScience. 2025 Jan 16;28(2):111802. doi: 10.1016/j.isci.2025.111802. eCollection 2025 Feb 21.
6
The impact of the soluble epoxide hydrolase cascade on periodontal tissues.可溶性环氧化物水解酶级联反应对牙周组织的影响。
Front Dent Med. 2023 Feb 1;4:1129371. doi: 10.3389/fdmed.2023.1129371. eCollection 2023.
7
Cytokines in gingivitis and periodontitis: from pathogenesis to therapeutic targets.龈炎和牙周炎中的细胞因子：从发病机制到治疗靶点。
Front Immunol. 2024 Aug 26;15:1435054. doi: 10.3389/fimmu.2024.1435054. eCollection 2024.
8
Correlation Between Gut Microbiota Composition and Serum Interleukin 17 (IL-17) in Mice With Type 2 Diabetes and Experimental Periodontitis.2型糖尿病合并实验性牙周炎小鼠肠道微生物群组成与血清白细胞介素17（IL-17）的相关性
Cureus. 2024 Aug 28;16(8):e68005. doi: 10.7759/cureus.68005. eCollection 2024 Aug.
9
Patent Mining on the Use of Antioxidant Phytochemicals in the Technological Development for the Prevention and Treatment of Periodontitis.关于抗氧化植物化学物质在牙周炎预防和治疗技术开发中的应用的专利挖掘
Antioxidants (Basel). 2024 May 3;13(5):566. doi: 10.3390/antiox13050566.
10
IL-23/IL-17 axis levels in gingival crevicular fluid of subjects with periodontal disease: a systematic review.牙周病患者龈沟液中白细胞介素-23/白细胞介素-17轴水平：一项系统评价
BMC Oral Health. 2024 Mar 2;24(1):302. doi: 10.1186/s12903-024-04077-0.
本文引用的文献
1
Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities.髓系造血的适应性先天免疫训练与炎症合并症相关联。
Cell. 2022 May 12;185(10):1709-1727.e18. doi: 10.1016/j.cell.2022.03.043. Epub 2022 Apr 27.
2
Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier.纤维蛋白是口腔黏膜屏障中性粒细胞效应功能的关键调节因子。
Science. 2021 Dec 24;374(6575):eabl5450. doi: 10.1126/science.abl5450.
3
Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity.在自身免疫中，类干细胞样的肠道 Th17 细胞可分化为致病性效应 T 细胞。
Cell. 2021 Dec 22;184(26):6281-6298.e23. doi: 10.1016/j.cell.2021.11.018. Epub 2021 Dec 6.
4
Human gut bacterial metabolism drives Th17 activation and colitis.人体肠道细菌代谢物驱动 Th17 细胞激活并引发结肠炎。
Cell Host Microbe. 2022 Jan 12;30(1):17-30.e9. doi: 10.1016/j.chom.2021.11.001. Epub 2021 Nov 24.
5
Th17 Cells in Periodontitis and Its Regulation by A20.牙周炎中的 Th17 细胞及其受 A20 的调控
Front Immunol. 2021 Sep 7;12:742925. doi: 10.3389/fimmu.2021.742925. eCollection 2021.
6
The oral microbiome: Role of key organisms and complex networks in oral health and disease.口腔微生物群：关键微生物和复杂网络在口腔健康与疾病中的作用
Periodontol 2000. 2021 Oct;87(1):107-131. doi: 10.1111/prd.12393.
7
Application of Ligature-Induced Periodontitis in Mice to Explore the Molecular Mechanism of Periodontal Disease.结扎诱导牙周炎在小鼠模型中用于探索牙周病的分子机制。
Int J Mol Sci. 2021 Aug 18;22(16):8900. doi: 10.3390/ijms22168900.
8
Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity.人类口腔黏膜细胞图谱揭示了调节组织免疫的基质-中性粒细胞轴。
Cell. 2021 Jul 22;184(15):4090-4104.e15. doi: 10.1016/j.cell.2021.05.013. Epub 2021 Jun 14.
9
Microbial signatures of health, gingivitis, and periodontitis.健康、牙龈炎和牙周炎的微生物特征。
Periodontol 2000. 2021 Jun;86(1):57-78. doi: 10.1111/prd.12362. Epub 2021 Mar 10.
10
Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities.牙周病与炎症性合并症相关的局部和全身机制。
Nat Rev Immunol. 2021 Jul;21(7):426-440. doi: 10.1038/s41577-020-00488-6. Epub 2021 Jan 28.
Zotero 插件