体力活动与阿尔茨海默病病理和认知的关系：CABLE 研究。

Associations of Physical Activity with Alzheimer's Disease Pathologies and Cognition: The CABLE Study.

机构信息

Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.

Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

出版信息

J Alzheimers Dis. 2022;89(2):483-492. doi: 10.3233/JAD-220389.

DOI:10.3233/JAD-220389

PMID:35871345

Abstract

BACKGROUND

The associations of physical activity with Alzheimer's disease (AD) pathologies remain controversial.

OBJECTIVE

To quantitatively assess the association between the frequency of physical activity with cerebrospinal fluid (CSF) biomarkers in AD and further explore the mechanism by which AD pathologies regulate the correlation between physical activity and cognition.

METHODS

A total of 918 participants without dementia from Chinese Alzheimer's Biomarker and Lifestyle (CABLE) were examined in this population-based cross-sectional study. Multiple linear models were used to evaluate the associations of physical activity with CSF biomarkers and cognition. Moreover, mediation analyses were conducted to investigate the potential relationships between physical activity, AD pathologies, and cognitive function.

RESULTS

Regular physical activity was positively associated with CSF Aβ42 (p < 0.001) and Aβ42/40 (p < 0.001), while it was negatively associated with p-tau/Aβ42 (p < 0.001) and t-tau/Aβ42 (p < 0.001). Of all participants, regular physical activity was associated with increased cognitive function (p < 0.001). The interaction effect indicated that age moderated the association between physical activity frequency and CSF Aβ42 (p = 0.014) and p-tau/Aβ42 (p = 0.041). The impact of physical activity on cognition was mediated in part by amyloid pathologies, accounting for 4.87% to 21.56% of the total effect (p < 0.05).

CONCLUSION

This study showed the beneficial impact of physical activity on AD pathologies and cognition in participants without dementia.

摘要

背景

体力活动与阿尔茨海默病（AD）病理的关联仍存在争议。

目的

定量评估体力活动频率与 AD 患者脑脊液（CSF）生物标志物之间的相关性，并进一步探讨 AD 病理如何调节体力活动与认知之间的相关性。

方法

本研究为基于人群的横断面研究，共纳入 918 名无痴呆的中国阿尔茨海默病生物标志物和生活方式（CABLE）研究参与者。采用多元线性模型评估体力活动与 CSF 生物标志物和认知之间的关联。此外，还进行了中介分析，以探讨体力活动、AD 病理与认知功能之间的潜在关系。

结果

有规律的体力活动与 CSF Aβ42（p < 0.001）和 Aβ42/40（p < 0.001）呈正相关，与 p-tau/Aβ42（p < 0.001）和 t-tau/Aβ42（p < 0.001）呈负相关。在所有参与者中，有规律的体力活动与认知功能的提高呈正相关（p < 0.001）。交互作用分析表明，年龄调节了体力活动频率与 CSF Aβ42（p = 0.014）和 p-tau/Aβ42（p = 0.041）之间的关联。体力活动对认知的影响部分通过淀粉样蛋白病理介导，占总效应的 4.87%至 21.56%（p < 0.05）。