Department of Chemistry, Liaoning University, 66 Chongshan Road, Shenyang, Liaoning, 110036, P. R. China.
Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, 110016, P. R. China.
Small. 2022 Aug;18(33):e2203283. doi: 10.1002/smll.202203283. Epub 2022 Jul 24.
Exploring antibacterial nanomaterials with excellent catalytic antibacterial properties has always been a hot research topic. However, the construction of nanomaterials with robust antibacterial activity at the atomic level remains a great challenge. Here a fully-exposed Pd cluster atomically-dispersed on nanodiamond-graphene (Pd /ND@G) with excellent catalytic antibacterial properties is reported. The fully-exposed Pd cluster nanozyme provides atomically-dispersed Pd cluster sites that facilitate the activation of oxygen. Notably, the oxidase-like catalytic performance of the fully-exposed Pd cluster nanozyme is much higher than that of Pd single-atom oxidase mimic, Pd nanoparticles oxidase mimic and even the previously reported palladium-based oxidase mimics. Under the density functional theory (DFT) calculations, the Pd cluster sites can efficiently catalyze the decomposition of oxygen to generate reactive oxygen species, resulting in strong antibacterial properties. This research provides a valuable insight to the design of novel oxidase mimic and antibacterial nanomaterial.
探索具有优异催化抗菌性能的抗菌纳米材料一直是一个热门研究课题。然而，在原子水平上构建具有强大抗菌活性的纳米材料仍然是一个巨大的挑战。在这里，我们报道了一种具有优异催化抗菌性能的完全暴露的 Pd 团簇原子分散在纳米金刚石-石墨烯（Pd/ND@G）上。完全暴露的 Pd 团簇纳米酶提供了原子分散的 Pd 团簇位点，有利于氧气的激活。值得注意的是，完全暴露的 Pd 团簇纳米酶的类氧化酶催化性能远高于 Pd 单原子氧化酶模拟物、Pd 纳米颗粒氧化酶模拟物，甚至是之前报道的基于钯的氧化酶模拟物。在密度泛函理论（DFT）计算中，Pd 团簇位点可以有效地催化氧气的分解，生成活性氧物种，从而具有很强的抗菌性能。这项研究为新型氧化酶模拟物和抗菌纳米材料的设计提供了有价值的见解。
