Amols H I, Weinhous M S, Reinstein L E
Med Phys. 1987 Mar-Apr;14(2):291-5. doi: 10.1118/1.596140.
Thirty-two radiotherapy centers in the USA and Canada cooperated in a study of the variability of clinical thermoluminescent dosimetry (TLD) systems. The primary purpose of the survey was to ascertain the accuracy of TLD for the determination of in vivo dose measurements. Each participating institution provided two TLD packets for irradiation on a Clinac 4, at a prearranged time. Two batch irradiations were made. Thirty-two TLD packets, one from each institution, were uniformly irradiated to a dose of 22.35 cGy (known by us, but not by the participants). A second group of 32 packets were likewise irradiated to a dose of 179.0 cGy. Participants were told only that their TLD's would be irradiated to doses between 10 and 50 cGy, and 100 to 200 cGy. TLD's were then returned to the institutions of origin for readout, and the doses reported to us for analysis. Calibration factors, readout and annealing procedures, etc., were all established independently by each participant. Although these procedures varied widely between institutions, the mean values of the reported doses were within 5% and 3% of the expected values for the low and high doses, respectively. Standard deviations in the reported doses were 10% and 5%. Also of interest, however, is the finding that 22% (i.e., 14 out of 64) of the dose reportings were in error by more than 10%. The implications of these findings vis à vis radiotherapy are discussed.
美国和加拿大的32个放射治疗中心合作开展了一项关于临床热释光剂量测定（TLD）系统变异性的研究。该调查的主要目的是确定TLD用于体内剂量测量的准确性。每个参与机构提供两个TLD包，在预先安排的时间在Clinac 4上进行照射。进行了两组照射。32个TLD包，每个机构一个，被均匀照射到22.35 cGy的剂量（我们知道，但参与者不知道）。第二组32个包同样被照射到179.0 cGy的剂量。只告知参与者他们的TLD将被照射到10至50 cGy以及100至200 cGy之间的剂量。然后将TLD返回原机构进行读数，并将报告的剂量提供给我们进行分析。校准因子、读数和退火程序等均由每个参与者独立确定。尽管这些程序在各机构之间差异很大，但报告剂量的平均值分别在低剂量和高剂量预期值的5%和3%以内。报告剂量的标准偏差分别为10%和5%。然而，同样值得关注的是，发现22%（即64个中的14个）的剂量报告误差超过10%。讨论了这些发现对放射治疗的影响。
