Department of Medical Oncology, Sapporo Medical University School of Medicine, Japan.
Department of Hematology, Sapporo Medical University School of Medicine, Japan.
Intern Med. 2023 Mar 1;62(5):775-778. doi: 10.2169/internalmedicine.0010-22. Epub 2022 Jul 22.
Multiple myeloma (MM) is a cancer characterized by the expansion of plasma cells in the bone marrow. Survival times of patients with MM have increased due to the development of novel therapeutic agents. We herein highlight three MM cases that had a poor prognosis despite treatment with novel therapeutic agents. Of note, all patients presented with hyperammonemia that led to a consciousness disorder. The outcome for patients with MM showing high levels of serum ammonia continues to be poor, even with the use of novel therapies. For such patients showing a consciousness disorder, hyperammonemia should be considered as a possible cause.
多发性骨髓瘤（MM）是一种以骨髓浆细胞扩增为特征的癌症。由于新型治疗药物的开发，MM 患者的生存时间有所延长。在此，我们重点介绍了三例尽管使用了新型治疗药物但预后仍较差的 MM 病例。值得注意的是，所有患者均表现出高氨血症，导致意识障碍。即使使用新型疗法，MM 患者的血清氨水平较高时，预后仍然较差。对于出现意识障碍的此类患者，高氨血症应被视为可能的病因。
