Department of Biological Sciences, Institute of Eminence, Birla Institute of Technology and Sciences-Pilani, Hyderabad Campus, Hyderabad, Telangana, India.
Department of Pulmonary Medicine, Sir Ganga Ram Hospital, New Delhi, India.
Clin Nutr ESPEN. 2022 Aug;50:8-14. doi: 10.1016/j.clnesp.2022.05.026. Epub 2022 Jun 4.
COVID19 has emerged as one of the worst pandemics in the history of mankind. Several vaccines have been approved by different government agencies worldwide, but data on their efficacy and safety are limited, and distribution remains a massive challenge. As per WHO, personal immunity is vital for protection against COVID19. Earlier, Vitamin C-mediated pathways have been shown to play critical role in boosting immunity attributed to its antioxidant properties. Recently, the involvement of such pathways in protection against COVID19 has been suggested. The controlled doses of Vitamin C administered through intravenous (IV) injections are being studied for determining its role in the prognosis of COVID19. In this article, we have discussed the potential role of Vitamin C in the management in COVID19 patients and presented recent clinical trials data. Additionally, we have elaborated the possibility of administering Vitamin C through inhalers in order to achieve local high concentration and the challenges of such approach.
COVID19 已成为人类历史上最严重的大流行病之一。世界上许多政府机构已经批准了几种疫苗，但关于它们的疗效和安全性的数据有限，且分配仍然是一个巨大的挑战。根据世界卫生组织的说法，个人免疫力对于预防 COVID19 至关重要。早期的研究表明，维生素 C 介导的途径通过其抗氧化特性在增强免疫力方面发挥着关键作用。最近，有人提出了这些途径在预防 COVID19 方面的作用。通过静脉注射（IV）给予受控剂量的维生素 C 正在研究中，以确定其在 COVID19 预后中的作用。在本文中，我们讨论了维生素 C 在 COVID19 患者管理中的潜在作用，并介绍了最近的临床试验数据。此外，我们还阐述了通过吸入器给予维生素 C 的可能性，以达到局部高浓度，以及这种方法的挑战。
