Liu Lian, Xu Ling, Lin Chen
Institute of Hematology, School of Medicine, Jinan University, Guangzhou 510632, China.
Department of Microbiology and Immunology, School of Medicine, Jinan University, Guangzhou 510632, China.
Blood Sci. 2020 Jul 25;2(3):76-78. doi: 10.1097/BS9.0000000000000050. eCollection 2020 Jul.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was the third zoonotic coronavirus to have an outbreak in the first two decades of the 21st century. Human-to-human transmission of this virus has threatened thousands of lives around the world. SARS-CoV-2 shares 79% and 50% sequence homology with severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), respectively. Like SARS-CoV and MERS-CoV infection, evidence has shown that SARS-CoV-2 infection also causes acute tissue damage due to a pathological immune response, particularly in severe cases. T cells play an important role in virus clearance and prevention, and in this paper, we summarize dynamic changes in the T cell count, subsets, phenotype, and function in Coronavirus Disease 2019 (COVID-19) patients based on current clinical reports. This review may help to better understand the pathological immune response of T cells and facilitate making better therapeutic strategies for patients with SARS-CoV-2 infection.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是21世纪前二十年中出现疫情的第三种人畜共患冠状病毒。这种病毒的人际传播已经威胁到全球数千人的生命。SARS-CoV-2与严重急性呼吸综合征冠状病毒（SARS-CoV）和中东呼吸综合征冠状病毒（MERS-CoV）的序列同源性分别为79%和50%。与SARS-CoV和MERS-CoV感染一样，有证据表明，SARS-CoV-2感染也会由于病理性免疫反应导致急性组织损伤，尤其是在重症病例中。T细胞在病毒清除和预防中发挥着重要作用，在本文中，我们根据当前临床报告总结了2019冠状病毒病（COVID-19）患者T细胞计数、亚群、表型和功能的动态变化。这篇综述可能有助于更好地理解T细胞的病理性免疫反应，并有助于为SARS-CoV-2感染患者制定更好的治疗策略。
