Kushkestani Mehdi, Parvani Mohsen, Moghadassi Mahsa, Kazemzadeh Yaser, Moradi Kiandokht
Faculty of Physical Education and Sport Sciences, Allameh Tabataba'i University, Tehran, Iran.
Department of Exercise Physiology, Islamic Azad University, Tehran North Branch, Tehran, Iran.
Caspian J Intern Med. 2022;13(Suppl 3):148-154. doi: 10.22088/cjim.13.0.148.
Hypertension disease as an absolute risk factor of Covid-19 disease has been well-proven in recent evidence. The factors such as the use of antihypertensive drugs, protein expression, and compensatory axes resulted in hypertension disease playing very important roles in the occurrence of this problem. In this review study, we first attempted to investigate the higher chance reason for Covid-19 disease in people with high blood pressure; then we examined the related mechanisms, and finally, we reported the differences and similarities between people with high blood pressure and athletes. All in all, we concluded that people who exercise regularly, the same as hypertensive patients (Compensatory mechanism) are more susceptible to COVID-19 infection due to the high concentration of ACE2 (Physiological mechanism) caused by exercise adaptation, but for the low level of ANG2 (Systematic and gene expression) these individuals (Active subjects) indicate fewer complications and severity symptoms of COVID-19 such as dyspnea, hospitalization and, heart disease compared with hypertensive patients.
高血压疾病作为新冠病毒疾病的一个绝对风险因素，在最近的证据中已得到充分证实。诸如使用抗高血压药物、蛋白质表达和代偿轴等因素，使得高血压疾病在这一问题的发生中发挥着非常重要的作用。在这项综述研究中，我们首先试图探究高血压患者感染新冠病毒疾病几率更高的原因；然后我们研究了相关机制，最后，我们报告了高血压患者与运动员之间的异同。总而言之，我们得出结论，经常锻炼的人，与高血压患者一样（代偿机制），由于运动适应导致ACE2浓度升高（生理机制），更容易感染新冠病毒，但由于血管紧张素2水平较低（系统和基因表达），这些个体（活跃受试者）与高血压患者相比，新冠病毒感染的并发症和严重症状如呼吸困难、住院和心脏病更少。
