Martsevich Sergey Yu, Lukina Yulia V, Kutishenko Natalia P, Guseynova Elmira T
Department of Preventive Pharmacotherapy, National Medical Research Center for Therapy and Preventive Medicine, Petroverigsky per. 10, Moscow, Russia.
Caspian J Intern Med. 2022;13(Suppl 3):199-203. doi: 10.22088/cjim.13.0.199.
To assess the influence of the COVID-19 (Coronavirus Disease 2019 pandemic on treatment adherence by patients with CHF (Chronic heart failure) and to determine the factors associated with changing adherence during home-isolation.
The survey was conducted in patients participating in the COMPLIANCE study (ClinicalTrials.gov. NCT04262583). Thirty-one patients, included into in the COMPLIANCE study before March 1, 2020, were interviewed through phone calls. A modified adherence scale of the National Society for Evidence-Based Pharmacotherapy was used, which permits to assess of overall adherence, adherence to particular drugs and the main causes for non-adherence.
In the whole group of patients, only a tendency to reduced overall adherence was registered during the COVID-19 pandemic (р=0,256). Significant differences in the rate of adherence deterioration were revealed for angiotensin-converting enzyme (ACE) inhibitors (p=0.031) and for statins (p=0.002). The reasons for non-adherence were lack of opportunity to contact with a physician, inability to perform investigations necessary for correcting prescribed pharmacotherapy, and side effects.
A tendency to deterioration of adherence to prescribed pharmacotherapy was revealed during the COVID-19 pandemic. A significant decline in adherence was registered to ACE inhibitors and statins.
评估2019冠状病毒病（COVID-19）大流行对慢性心力衰竭（CHF）患者治疗依从性的影响，并确定居家隔离期间依从性变化的相关因素。
对参与COMPLIANCE研究（ClinicalTrials.gov. NCT04262583）的患者进行调查。通过电话访谈了2020年3月1日前纳入COMPLIANCE研究的31名患者。使用了基于循证药物治疗学会修改后的依从性量表，该量表可评估总体依从性、对特定药物的依从性以及不依从的主要原因。
在整个患者组中，COVID-19大流行期间仅出现总体依从性降低的趋势（р=0.256）。血管紧张素转换酶（ACE）抑制剂（p=0.031）和他汀类药物（p=0.002）的依从性恶化率存在显著差异。不依从的原因包括无法与医生联系、无法进行纠正处方药物治疗所需的检查以及副作用。
COVID-19大流行期间发现患者对处方药物治疗的依从性有恶化趋势。ACE抑制剂和他汀类药物的依从性显著下降。
