杜兴氏肌肉营养不良症患者血小板中的血清素摄取。
Serotonin uptake in blood platelets of Duchenne muscular dystrophy patients.
作者信息
Arora R C, Kuncl R W, Morgan J, Cohen L, Meltzer H Y
出版信息
Muscle Nerve. 1987 May;10(4):359-62. doi: 10.1002/mus.880100413.
Serotonin (5-HT) uptake was studied in the blood platelets of 10 patients with Duchenne-type muscular dystrophy (DMD) and 7 age-matched controls. Vmax (maximum number of uptake sites) of platelet 5-HT uptake in the DMD patients was significantly less than that of the normal controls. There was no difference in the affinity for 5-HT (Km) between the two groups. There was a significant negative correlation between serum creatine kinase activity and Km of 5-HT uptake in blood platelets of these patients. However, no correlation was found between Km or Vmax and ambulatory status of DMD.
对10例杜兴氏型肌营养不良症（DMD）患者和7名年龄匹配的对照者的血小板进行了血清素（5-羟色胺，5-HT）摄取研究。DMD患者血小板5-HT摄取的Vmax（摄取位点的最大数量）显著低于正常对照者。两组之间对5-HT的亲和力（Km）没有差异。这些患者血清肌酸激酶活性与血小板5-HT摄取的Km之间存在显著负相关。然而，未发现Km或Vmax与DMD的行走状态之间存在相关性。
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