Thies-Flechtner K, Weigel I, Müller-Oerlinghausen B
Department of Psychiatry, Free University of Berlin, Germany.
Pharmacopsychiatry. 1994 Jul;27 Suppl 1:4-6. doi: 10.1055/s-2007-1014316.
There is strong evidence that platelet 5-HT uptake is reduced during depressive illness, yet it is an open question whether this abnormality can be reverted to normal by successful treatment. The effect of longterm lithium treatment (> 2 years of continuous therapy) on 5-HT uptake of 37 euthymic affective patients without relevant additional medication was investigated. There was no difference in 5-HT uptake kinetics between the whole group of patients and age- and sex-matched healthy controls. The subgroups of unipolar patients and patients with minor recurrences during prophylaxis tended to have lower Vmax values of 5-HT uptake. The results generally support the hypothesis of a relationship between successful lithium treatment and normalization of 5-HT uptake.
有强有力的证据表明，在抑郁性疾病期间血小板5-羟色胺摄取减少，但这种异常是否能通过成功治疗恢复正常仍是一个悬而未决的问题。研究了长期锂治疗（连续治疗>2年）对37例无相关额外用药的心境正常的情感障碍患者5-羟色胺摄取的影响。患者全组与年龄和性别匹配的健康对照组之间的5-羟色胺摄取动力学没有差异。单相患者亚组和预防期间有轻微复发的患者往往具有较低的5-羟色胺摄取Vmax值。这些结果总体上支持了成功的锂治疗与5-羟色胺摄取正常化之间存在关联的假设。
