铜催化乙炔与迈克尔受体的碳硼化反应。

Cheng Tairan, Liu Boxiang, Wu Rui, Zhu Shifa

Key Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology Guangzhou 510640 P. R. China

Chem Sci. 2022 Jun 8;13(25):7604-7609. doi: 10.1039/d2sc02306g. eCollection 2022 Jun 29.

A copper-catalyzed three-component carboboration of acetylene with BPin and Michael acceptors is reported. In this reaction, a cheap and abundant C2 chemical feedstock, acetylene, was used as a starting material to afford -alkenyl boronates bearing a homoallylic carbonyl group. The reaction was robust and could be reliably performed on the molar scale. Furthermore, the resulting -alkenyl boronates could be converted to diverse functionalized molecules with ease.

报道了一种铜催化的乙炔与频哪醇硼烷（BPin）和迈克尔受体的三组分碳硼化反应。在该反应中，一种廉价且丰富的C2化学原料乙炔被用作起始原料，以得到带有高烯丙基羰基的β-烯基硼酸酯。该反应性能良好，能够在摩尔规模上可靠地进行。此外，所得的β-烯基硼酸酯可以轻松地转化为各种功能化分子。