Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Biomed Res Int. 2022 Jul 15;2022:8501362. doi: 10.1155/2022/8501362. eCollection 2022.
The aim of this study was to assess the relationship between early developmental kinetics and the competence to result in a live birth as well as the impact of maternal age and the number of retrieved oocytes. This retrospective cohort study included 3,021 single-embryo transfer cycles and assessed live birth outcomes paired with morphokinetic data; 1,412 transfers resulted in live births (LB), and 1,609 did not (NLB). Early morphokinetic parameters between LB and NLB embryos were compared from patients stratified into four age groups (20-25, 26-30, 31-36, and ≥37 years) and between embryos in the same competence groups within the age groups. Early morphokinetic parameters were also compared between LB and NLB embryos from patients stratified into four groups based on the number of oocytes harvested (≤7, 8-14, 15-21, and ≥22). The association between morphokinetic parameters and LB was tested using univariate and multivariate analyses. This study indicated that embryos resulting in LB generally exhibit faster developmental dynamic parameters than embryos that do not. However, this difference decreased in the younger (20-25 years) and older (≥37 years) age groups. In addition, when the number of harvested oocytes was low (≤7) or high (≥22), this difference was less obvious. The morphokinetic parameters of embryonic cleavage are an effective reference value for embryo selection strategies aimed at increasing live birth rates, especially for patients aged 26-36 years, with 8-21 harvested oocytes.
本研究旨在评估早期发育动力学与活产能力的关系，以及母体年龄和获得的卵母细胞数量的影响。这项回顾性队列研究包括 3021 个单胚胎移植周期，并评估了与形态动力学数据配对的活产结局；1412 次移植导致活产（LB），1609 次移植未导致活产（NLB）。从分为四个年龄组（20-25 岁、26-30 岁、31-36 岁和≥37 岁）的患者中比较 LB 和 NLB 胚胎的早期形态动力学参数，以及同一年龄组内具有相同能力组的胚胎之间的早期形态动力学参数。还根据获得的卵母细胞数量（≤7、8-14、15-21 和≥22）将患者分为四组，比较 LB 和 NLB 胚胎的早期形态动力学参数。使用单变量和多变量分析测试形态动力学参数与 LB 的关系。本研究表明，导致 LB 的胚胎通常表现出比不导致 LB 的胚胎更快的发育动态参数。然而，这种差异在较年轻（20-25 岁）和较年长（≥37 岁）的年龄组中减小。此外，当获得的卵母细胞数量较少（≤7）或较多（≥22）时，这种差异不太明显。胚胎卵裂的形态动力学参数是一种有效的参考值，可用于旨在提高活产率的胚胎选择策略，特别是对于年龄在 26-36 岁之间、获得 8-21 个卵母细胞的患者。
