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体外受精/卵胞浆内单精子注射中不同胚胎移植策略对低质量胚胎的影响——胚胎发育、围产期及新生儿结局分析

Outcomes of different transfer strategies for in vitro fertilization/intracytoplasmic sperm injection with poor-quality embryos-Analysis of embryonic development, perinatal period, and neonatal outcomes.

作者信息

Jin Lei, Li Zhou, Si Keyi, Ma Bingxin, Ren Xinling, Huang Bo

机构信息

Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 430030.

出版信息

Heliyon. 2024 Nov 2;10(21):e40103. doi: 10.1016/j.heliyon.2024.e40103. eCollection 2024 Nov 15.

Abstract

During the in vitro fertilization and embryo transfer process, some expectant mothers may not have good embryos to choose from before the embryo transfer. Recommendations for this condition are currently unclear, and relevant clinical and neonatal outcomes are still lacking. This study analyzed the outcomes of poor-quality embryo transfers, including fetal outcomes, in the fresh cycle and frozen-thawed embryo transfer cycle. Embryos were also analyzed for abnormalities during the cleavage stage. The results indicate that in the absence of good embryos, clinicians and embryologists could advise expectant mothers to continue culturing the embryos to the blastocyst stage and undergo transfer if blastocysts are formed. This finding can also be used as a reference for many expectant mothers with frozen embryos that have not yet been thawed.

摘要

在体外受精和胚胎移植过程中,一些准妈妈在胚胎移植前可能没有优质胚胎可供选择。目前对于这种情况的建议尚不清楚,且仍缺乏相关的临床和新生儿结局数据。本研究分析了新鲜周期和冻融胚胎移植周期中低质量胚胎移植的结局,包括胎儿结局。同时还分析了胚胎在卵裂期的异常情况。结果表明,在没有优质胚胎的情况下,临床医生和胚胎学家可以建议准妈妈将胚胎继续培养至囊胚期,若形成囊胚则进行移植。这一发现也可为许多尚未解冻冷冻胚胎的准妈妈提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1093/11570467/eab00e1559ed/gr1.jpg

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