Department of Endocrinology, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China.
Department of Anorectal Surgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, China.
Comput Math Methods Med. 2022 Jul 15;2022:1863243. doi: 10.1155/2022/1863243. eCollection 2022.
Biomarkers in predicting the stages of nephropathy associated with type 2 diabetes mellitus are urgent, and adiponectin may be a promising biomarker. This meta-analysis examined the association of serum adiponectin level with the stages of type 2 diabetic nephropathy.
Databases including PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), and Wan Fang were searched for published studies on adiponectin and type 2 diabetic kidney disease. The Newcastle-Ottawa scale was used to assess the quality of the literature. STATA 14.0 was used to conduct the statistical analysis.
Thirty-four studies with 5254 patients were included in this meta-analysis. The results of this study show that there was no significant difference in serum adiponectin level between normoalbuminuria and the control group (mean difference = -0.42, 95% CI [-1.23, 0.40]), while serum adiponectin level was positively correlated with the severity of type 2 diabetic kidney disease. The serum adiponectin level in type 2 diabetic kidney disease patients ranks as macroalbuminuria > microalbuminuria > normoalbuminuria.
Serum adiponectin level might be an important marker to predict the progression of type 2 diabetic kidney disease.
预测 2 型糖尿病相关肾病分期的生物标志物迫在眉睫，脂联素可能是一种很有前途的生物标志物。本荟萃分析研究了血清脂联素水平与 2 型糖尿病肾病分期的关系。
检索PubMed、Cochrane Library、EMBASE、中国知网（CNKI）和万方数据库，以评估脂联素与 2 型糖尿病肾病的关系。使用纽卡斯尔-渥太华量表评估文献质量。使用 STATA 14.0 进行统计分析。
本荟萃分析纳入了 34 项研究，共 5254 名患者。结果表明，正常白蛋白尿组与对照组之间血清脂联素水平无显著差异（均数差=-0.42，95%CI[-1.23,0.40]），而血清脂联素水平与 2 型糖尿病肾病的严重程度呈正相关。2 型糖尿病肾病患者的血清脂联素水平依次为大量白蛋白尿>微量白蛋白尿>正常白蛋白尿。
血清脂联素水平可能是预测 2 型糖尿病肾病进展的重要标志物。
