Department of Ophthalmology Laboratory, The Fourth Affiliated Hospital of China Medical University, Shenyang 110006, China.
Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang 110001, China.
J Diabetes Res. 2020 Feb 3;2020:2315607. doi: 10.1155/2020/2315607. eCollection 2020.
Diabetic nephropathy (DN) is an important cause of end-stage renal disease and is recognized as a public health problem worldwide. However, there have been no nationwide surveys of DN prevalence in China. This study is aimed at estimating the pooled prevalence of DN among patients with type 2 diabetes in China.
Published studies on the prevalence of DN among patients with type 2 diabetes published from January 1980 to October 2019 were systematically reviewed using PubMed, Embase, Google Scholar, Chinese Wanfang databases, and Chinese National Knowledge Infrastructure. The pooled prevalence of DN was estimated with the random effects model using R software. Prevalence estimates were also stratified by study design, methodological approach, and study population characteristics.
Thirty studies with a total of 79,364 participants were included in our study. The overall pooled prevalence of DN was 21.8% [95% confidence interval (CI): 18.5-25.4%]. Subgroup analysis found that the prevalence of DN varied significantly according to different DM and DN diagnostic criteria ( < 0.05); the pooling estimate was the highest in the west region of 41.3%, followed by that in the east region of China with 22.3%, northeast region with 20.7%, and central region with 15.6% ( < 0.05); the pooling estimate was the highest in the west region of 41.3%, followed by that in the east region of China with 22.3%, northeast region with 20.7%, and central region with 15.6% ( < 0.05); the pooling estimate was the highest in the west region of 41.3%, followed by that in the east region of China with 22.3%, northeast region with 20.7%, and central region with 15.6% (.
The prevalence of DN is high in Chinese patients with type 2 diabetes and shows geographic and gender variation. These data indicate that national strategies aimed at primary and secondary prevention of DN and screening programs for DN are urgently needed to reduce the risk and burden of DN in China.
糖尿病肾病（DN）是终末期肾病的重要病因，被认为是全球范围内的公共卫生问题。然而，中国还没有全国性的 DN 患病率调查。本研究旨在估计中国 2 型糖尿病患者中 DN 的患病率。
系统检索了 1980 年 1 月至 2019 年 10 月期间发表的关于 2 型糖尿病患者中 DN 患病率的研究，使用 PubMed、Embase、Google Scholar、中国万方数据库和中国国家知识基础设施进行检索。使用 R 软件中的随机效应模型估算 DN 的总体患病率。患病率估计值还按研究设计、方法学方法和研究人群特征进行分层。
本研究共纳入 30 项研究，共计 79364 名参与者。DN 的总体患病率为 21.8%（95%置信区间：18.5%-25.4%）。亚组分析发现，根据不同的 DM 和 DN 诊断标准，DN 的患病率差异有统计学意义（<0.05）；西部地区的患病率最高，为 41.3%，其次是中国东部地区，为 22.3%，东北地区为 20.7%，中部地区为 15.6%（<0.05）；西部地区的患病率最高，为 41.3%，其次是中国东部地区，为 22.3%，东北地区为 20.7%，中部地区为 15.6%（<0.05）；西部地区的患病率最高，为 41.3%，其次是中国东部地区，为 22.3%，东北地区为 20.7%，中部地区为 15.6%（<0.05）。
中国 2 型糖尿病患者中 DN 的患病率较高，且存在地域和性别差异。这些数据表明，中国迫切需要制定国家一级和二级预防 DN 的策略以及开展 DN 筛查计划，以降低中国的 DN 风险和负担。
