Department of Clinical Laboratory, Yantaishan Hospital, Yantai 264000, China.
Department of Clinical Laboratory, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, China.
Comput Math Methods Med. 2022 Jul 15;2022:4074628. doi: 10.1155/2022/4074628. eCollection 2022.
In order to explore the clinical application value of color Doppler ultrasound (CDUS), mammography (MAM), and serum tumor marker carbohydrate antigen 153 (CA153) in screening breast cancer (BC) for high-risk women, a total of 38,241 women were surveyed by epidemiological questionnaire on BC high-risk factors. A total of 10,821 cases were screened, accounting for 28.30%. They were randomly divided into US, MAM, and CA153 and combined examination group which has no significant difference in high-risk factors. Breast cancer in high-risk population was screened by CDUS, MAM, and CA153 and combined examination. CA153 was detected by electroluminescence method. The positive detection rate of BC was 360.41/100,000 (39/10,821). The overall difference in the positive detection rate of BC among 10,821 cases in all age groups was statistically significant. The sensitivity and negative predictive value of combined examination were significantly improved compared with each single examination. Combined examination for BC screening can significantly improve the sensitivity of BC early diagnosis and reduce the missed diagnosis rate.
为了探讨彩色多普勒超声（CDUS）、乳房 X 线摄影术（MAM）和血清肿瘤标志物糖类抗原 153（CA153）在筛查乳腺癌（BC）高危女性中的临床应用价值，对 BC 高危因素进行了流行病学问卷调查，共调查了 38241 名妇女。共筛查出 10821 例，占 28.30%。随机分为 US、MAM 和 CA153 联合检查组，高危因素无明显差异。采用 CDUS、MAM 和 CA153 联合检查对高危人群进行乳腺癌筛查。CA153 采用电化学发光法检测。BC 的阳性检出率为 360.41/10 万（39/10821）。所有年龄组 10821 例患者 BC 阳性检出率的总体差异有统计学意义。与单项检查相比，联合检查对 BC 的灵敏度和阴性预测值均有显著提高。联合检查筛查 BC 可显著提高 BC 早期诊断的灵敏度，降低漏诊率。
