具有抗肿瘤活性的吡喃酮衍生物，来源于内生真菌sp. YN02-P-3。
Pyranone Derivatives With Antitumor Activities, From the Endophytic Fungus sp. YN02-P-3.
作者信息
Yu Chong, Nian Yin, Chen Huanhua, Liang Shuwen, Sun Mengyang, Pei Yuehu, Wang Haifeng
机构信息
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
出版信息
Front Chem. 2022 Jul 7;10:950726. doi: 10.3389/fchem.2022.950726. eCollection 2022.
Two new pyranone derivatives phomapyrone A (2) and phomapyrone B (3), one new coumarin 11 13-(+)-phomacumarin A (1), three known pyranones (4-6), together with three known amide alkaloids fuscoatramides A-C (7-9), as well as 9 11-(+)-ascosalitoxin (10) were isolated from the endophytic fungus sp. YN02-P-3, which was isolated from the healthy leaf tissue of a Paulownia tree in Yunnan Province, China. Their structures were elucidated using extensive NMR spectroscopic and HRESIMS data and by comparing the information with literature data. In addition, all compounds were tested for their cytotoxicity activity against human tumor cell lines, and the results showed that new compounds 1-3 showed moderate inhibitory activity against the HL-60 cell line with IC values of 31.02, 34.62, and 27.90 M, respectively.
从内生真菌YN02-P-3中分离得到两个新的吡喃酮衍生物苯并吡喃酮A（2）和苯并吡喃酮B（3）、一个新的香豆素11 13-(+)-苯并香豆素A（1）、三个已知的吡喃酮（4-6）、三个已知的酰胺生物碱福斯考特拉米德A-C（7-9）以及9 11-(+)-阿斯科沙毒素（10）。该内生真菌是从中国云南省一棵泡桐树的健康叶片组织中分离得到的。通过广泛的核磁共振光谱和高分辨电喷雾电离质谱数据，并与文献数据进行比较，阐明了它们的结构。此外，对所有化合物进行了针对人肿瘤细胞系的细胞毒性活性测试，结果表明新化合物1-3对HL-60细胞系显示出中等抑制活性，IC值分别为31.02、34.62和27.90 μM。
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