Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Front Cell Infect Microbiol. 2022 Jul 6;12:890511. doi: 10.3389/fcimb.2022.890511. eCollection 2022.
Acinetobacter baumannii (AB) infection has become a threat to global public health. AB is one of the main pathogens causing nosocomial infections, especially ventilator-associated pneumonia. AB easily develops resistance against a variety of antibiotics, which makes the treatment of AB infections difficult. Therefore, it is necessary to study new treatment plans like anti-infection immunity. Both animal models of AB infection and cell experiments show that macrophages are activated in the early stage of the immune response and regulate the recruitment of neutrophils, thus playing a role in clearing AB. AB components and the immune responses they induce can lead to injury of the infected organ, mostly in the lungs. Understanding the response of innate immunity to ABs at different stages after infection and the relationship between the response and lung injury can help to develop new immunotherapy methods and prevent lung injury. This article provides a comprehensive review of the response of neutrophils and macrophages to AB infection and their association with lung injury to develop effective therapies for AB infection and prevent lung injury.
鲍曼不动杆菌（AB）感染已成为全球公共卫生的威胁。AB 是引起医院获得性感染的主要病原体之一，尤其是呼吸机相关性肺炎。AB 容易对多种抗生素产生耐药性，这使得 AB 感染的治疗变得困难。因此，有必要研究新的治疗方案，如抗感染免疫。AB 感染的动物模型和细胞实验均表明，巨噬细胞在免疫反应的早期被激活，并调节中性粒细胞的募集，从而在清除 AB 方面发挥作用。AB 的成分及其诱导的免疫反应可导致感染器官损伤，主要发生在肺部。了解感染后不同阶段固有免疫对 AB 的反应以及该反应与肺部损伤之间的关系，有助于开发新的免疫治疗方法并预防肺部损伤。本文全面综述了中性粒细胞和巨噬细胞对 AB 感染的反应及其与肺部损伤的关系，以开发针对 AB 感染的有效治疗方法并预防肺部损伤。
