Multidrug resistant : A study on its pathogenesis and therapeutics.

The overuse of antibiotics has led to the global dissemination of , an increasingly challenging nosocomial pathogen. This review explores the medical significance along with the diverse resistance ability of . Intensive care units (ICUs) serve as a breeding ground for , as these settings harbour vulnerable patients and facilitate the spread of opportunistic microorganisms. belongs to the ESKAPE group of bacterial pathogens that are major contributors to antibiotic-resistant infections. The pathogenic nature of is particularly evident in seriously ill patients, causing pneumonia, wound infections, and other healthcare-associated infections. Historically considered benign, is a global threat due to its propensity for rapid acquisition of multidrug resistance phenotypes. The genus was formally recognized in 1968 following a comprehensive survey by Baumann ., highlighting the relationship between previously identified species and consolidating them under the name is characterized by its Gram-negative nature, dependence on oxygen, positive catalase activity, lack of oxidase activity, inability to ferment sugars, and non-motility. The DNA G+C content of species falls within a specific range. For diagnostic purposes, can be cultured on specific agar media, producing distinct colonies. The genus comprises numerous species those are associated with bloodstream infections with high mortality rates. Therefore, poses a significant challenge to global healthcare due to its multidrug resistance and ability to cause various infections. A comprehensive understanding of the mechanisms underlying its resistance acquisition and pathogenicity is essential for combating this healthcare-associated pathogen effectively.