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植物叶片、中果皮和外果皮对感染NK65的小鼠的体内抗疟原虫潜力

In Vivo Antiplasmodial Potential of the Leaf, Mesocarp, and Epicarp of the Plant in Mice Infected with NK65.

作者信息

Oluyori Abimbola Peter, Nwonuma Charles, Akpo Theresa, Inyinbor Adejumoke Abosede, Dada Oluwasogo Adewumi, Oladeji Oluwole Solomon, Ogunnupebi Temitope Aminat

机构信息

Industrial Chemistry Programme, Physical Sciences Department, Landmark University, Omu-Aran, Kwara State, Nigeria.

Landmark University SDG 3: Good Health and Well-Being, Landmark University, PMB 1001, Omu-Aran, Nigeria.

出版信息

Evid Based Complement Alternat Med. 2022 Jul 13;2022:4129045. doi: 10.1155/2022/4129045. eCollection 2022.

DOI:10.1155/2022/4129045
PMID:35873624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9300302/
Abstract

RESULTS

The presence of alkaloids, fats and oils, phenolic, and flavonoids was detected via the qualitative test which was confirmed from the result obtained from the GC-MS chromatogram of ethanolic leaves extract. The GC-MS chromatogram of the constituents analogous to the twenty peaks was analyzed as follows: dodecanoic acid (1.94%), 2-undecanone (3.42%), hexadecanoic acid (44.84%), oleic acid (7.45%), octadecanoic acid (8.41%), narcissidine (2.38%), 1-dotriacontanol (2.38%), -sitosterol (2.02%), and lupeol (1.42%). The total phenolics and flavonoids of 118 and 23.3702 mg/g were analyzed in the leaves extract. The leave extract exhibited inhibitory activity of 73.49% against free radicals which could lead to inflammation. The extracts and chloroquine-treated groups showed significant decrease in percentage parasitaemia with pronounced activity observed in chloroquine groups.

CONCLUSION

The curative and scavenging potencies of studied plant could be attributed to the metabolites analyzed and could guide the formulation of new pharmacophores against malaria infections and inflammations.

摘要

结果

通过定性试验检测到生物碱、油脂、酚类和黄酮类化合物的存在，这从乙醇叶提取物的气相色谱 - 质谱图（GC - MS）获得的结果得到了证实。对与二十个峰类似的成分的GC - MS色谱图分析如下：十二烷酸（1.94%）、2 - 十一酮（3.42%）、十六烷酸（44.84%）、油酸（7.45%）、十八烷酸（8.41%）、水仙苷（2.38%）、1 - 三十二烷醇（2.38%）、β - 谷甾醇（2.02%）和羽扇豆醇（1.42%）。叶提取物中总酚和黄酮类化合物分别为118和23.3702毫克/克。叶提取物对可能导致炎症的自由基表现出73.49%的抑制活性。提取物组和氯喹治疗组的疟原虫血症百分比显著降低，氯喹组观察到明显的活性。

结论

所研究植物的治疗和清除能力可归因于所分析的代谢物，并可为针对疟疾感染和炎症的新药团的配方提供指导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a54/9300302/a300b00ae772/ECAM2022-4129045.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a54/9300302/37ec5e32c1bd/ECAM2022-4129045.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a54/9300302/331e070c6439/ECAM2022-4129045.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a54/9300302/b685cfd25111/ECAM2022-4129045.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a54/9300302/a300b00ae772/ECAM2022-4129045.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a54/9300302/37ec5e32c1bd/ECAM2022-4129045.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a54/9300302/331e070c6439/ECAM2022-4129045.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a54/9300302/b685cfd25111/ECAM2022-4129045.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a54/9300302/a300b00ae772/ECAM2022-4129045.004.jpg

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