Akuodor Godwin Christian, Asika Ebere Chile, Nwobodo Ndubuisi Nwobodo, Ezeonu Chinonyelum Thecla, Essien Augustine Dick, Chilaka Kingsley Chimsorom, Nwachukwu Daniel Ckukwu
Department of Pharmacology and Therapeutics, Faculty of Medicine, Ebonyi State University, Abakaliki P.M.B. 053, Nigeria.
Department of Paediatrics, Faculty of Medicine, Ebonyi State University, Abakaliki P.M.B. 053, Nigeria.
J Tradit Chin Med. 2017 Aug;37(4):431-435.
To evaluate the in vivo antiplasmodial activity and the oral acute toxicity of the Bombax buonopozense root bark aqueous extract.
The in vivo antiplasmodial activity of the root bark aqueous extract of Bombax buonopozense against early and established rodent malaria infections in chloroquine sensitive Plasmodium berghei strain in mice was investigated, and oral acute toxicity of the aqueous root bark extract of Bombax buonopozense was also evaluated in mice.
The findings of this study revealed significant (P < 0.05) and dose dependent decrease in parasitaemia in the parasitized groups treated with varying doses of the extract (50-200 mg/kg p.o.) in both suppressive and curative tests. There was also significant decrease in parasitaemia density in the chloroquine treated group. The aqueous extract was found no toxicity in mice and the oral LD50 was determined to be greater than 5000 mg/kg.
Bombax buonopozense root bark aqueous extract possesses potent antiplasmodial activity and may therefore, serve as potential sources of new antimalarial agents.
评估布氏木棉根皮水提取物的体内抗疟活性及口服急性毒性。
研究了布氏木棉根皮水提取物对小鼠体内氯喹敏感的伯氏疟原虫株早期和已建立的啮齿动物疟疾感染的抗疟活性，并评估了布氏木棉根皮水提取物对小鼠的口服急性毒性。
本研究结果显示，在抑制和治疗试验中，用不同剂量提取物（50 - 200 mg/kg口服）处理的感染组寄生虫血症显著（P < 0.05）且呈剂量依赖性降低。氯喹处理组的寄生虫血症密度也显著降低。发现该水提取物对小鼠无毒性，口服半数致死量测定大于5000 mg/kg。
布氏木棉根皮水提取物具有强大的抗疟活性，因此可能成为新型抗疟药物的潜在来源。
