Petersen S
Acta Paediatr Scand. 1978 Sep;67(5):597-9. doi: 10.1111/j.1651-2227.1978.tb17808.x.
Twenty girls, aged 5-12 years, with recurrent urinary tract infections, were treated with methenamine hippurate, Hiprex, for a period of 12 months. The number of infections per patient per year was reduced from 3.1 to 0.7 (p less than 0.001). After prophylaxis was stopped this number increased to 1.4 which is a significantly higher incidence than occurred during treatment (p less than 0.05). A few girls complained of the taste but no side-effects were observed. Methenamine hippurate is a useful alternative in long-term prophylaxis against recurrent urinary tract infections in girls.
20名年龄在5至12岁之间、患有复发性尿路感染的女孩接受了马尿酸乌洛托品（商品名Hiprex）治疗，为期12个月。每位患者每年的感染次数从3.1次降至0.7次（p<0.001）。预防治疗停止后，这一数字增至1.4次，该发病率显著高于治疗期间（p<0.05）。少数女孩抱怨其味道，但未观察到副作用。马尿酸乌洛托品是长期预防女孩复发性尿路感染的一种有效替代药物。
