Brumfitt W, Cooper J, Hamilton-Miller J M
J Urol. 1981 Jul;126(1):71-4. doi: 10.1016/s0022-5347(17)54386-4.
We treated 99 female patients suffering from recurrent urinary infections with either 1 gm. methenamine hippurate every 12 hours or 50 mg. nitrofurantoin every 12 hours for intervals of up to 1 year. Monthly microbiological and clinical surveillance was done. Both treatments were effective in reducing the incidence of symptomatic attacks, with nitrofurantoin being more effective. The protective effect of prophylaxis continued after treatment had stopped, suggesting that a permanent beneficial action had been produced. Especially during the first month of treatment methenamine hippurate was tolerated better than nitrofurantoin: 28 per cent discontinued therapy with the latter owing to nausea.
我们对99名复发性尿路感染的女性患者进行了治疗，一组每12小时服用1克马尿酸乌洛托品，另一组每12小时服用50毫克呋喃妥因，治疗期长达1年。每月进行微生物学和临床监测。两种治疗方法在降低症状性发作的发生率方面均有效，其中呋喃妥因的效果更佳。停止治疗后，预防的保护作用仍在持续，这表明已产生了永久性的有益作用。特别是在治疗的第一个月，马尿酸乌洛托品的耐受性优于呋喃妥因：28%的患者因恶心而停止服用后者。
