Bruegger Dominik, Koth Anna-Lucia, Dysli Muriel, Goldblum David, Abegg Mathias, Tschopp Markus, Tappeiner Christoph
Department of Ophthalmology, Inselspital, Bern University Hospital, Bern, Switzerland.
Augenpraxis Untertor, Winterthur, Switzerland.
Front Neurol. 2022 Jul 7;13:898064. doi: 10.3389/fneur.2022.898064. eCollection 2022.
Optic neuritis usually leads to reduced color sensitivity. Most often, the change of red color, the so-called red desaturation, is tested in clinical routine. The aim of this study was to test the feasibility of the Reddesa chart, a new red desaturation test based on polarization, as a screening method for optic neuropathy.
A total of 20 patients with unilateral optic neuritis and 20 healthy controls were included in this prospective pilot study. Ophthalmological examination included assessment of best corrected visual acuity (BCVA), slit lamp examination, fundoscopy, testing of relative afferent pupillary defect (RAPD) and red desaturation with the red cup test and the Reddesa chart.
The mean BCVA in the optic neuritis group was 0.76 ± 0.36 in the affected eye (95% of eyes with RAPD, 75% of eyes with difference in the Reddesa test) and 1.28 ± 0.24 in the healthy eye, whereas in the control group, BCVA was 1.14 ± 0.11 in the right eye and 1.15 ± 0.14 in the left eye (none of the eyes with RAPD or abnormal Reddesa test). In our study, the Reddesa test showed a positive predictive value of 100% and a negative predictive value of 80% for detecting optic neuritis.
The Reddesa chart allows to quantify red desaturation and has the potential to be implemented as a screening test in clinical routine.
视神经炎通常会导致色觉敏感度降低。在临床常规检查中，最常检测的是红色变化，即所谓的红色饱和度降低。本研究的目的是测试一种基于偏振的新型红色饱和度测试——Reddesa图表作为视神经病变筛查方法的可行性。
本前瞻性试点研究共纳入20名单侧视神经炎患者和20名健康对照者。眼科检查包括最佳矫正视力（BCVA）评估、裂隙灯检查、眼底镜检查、相对传入性瞳孔障碍（RAPD）检测以及使用红色视杯测试和Reddesa图表进行红色饱和度检测。
视神经炎组患眼的平均BCVA为0.76±0.36（95%的患眼存在RAPD，75%的患眼在Reddesa测试中有差异），健眼为1.28±0.24；而对照组右眼的BCVA为1.14±0.11，左眼为1.15±0.14（均无RAPD或Reddesa测试异常）。在我们的研究中，Reddesa测试检测视神经炎时显示出100%的阳性预测值和80%的阴性预测值。
Reddesa图表能够量化红色饱和度降低情况，并且有潜力在临床常规检查中作为一种筛查测试来应用。
