Travis D, Thompson P
Department of Psychology, University of York, Heslington, UK.
Brain. 1989 Apr;112 ( Pt 2):283-303. doi: 10.1093/brain/112.2.283.
Measures of contrast sensitivity and colour vision were taken from a group of 18 multiple sclerosis patients. Contrast sensitivity losses, measured at 5 spatial frequencies and 4 temporal frequencies, were found to be significant in 11 patients. Red/green (Rayleigh equation) and green/blue (Engelking-Trendelenburg equation) Pickford-Nicolson anomaloscope settings were abnormal in 15 patients. Correlating each of the 20 spatiotemporal losses with the colour losses revealed that in 19 conditions the red/green loss was greater than the green/blue loss. None of the green/blue losses correlated significantly with spatiotemporal losses while between 2 and 8 cycles/deg 11/12 spatiotemporal conditions showed significant correlations with red/green colour loss. These results support a locus of damage before the cortex at a stage in the visual pathway where red/green chromatic information may be encoded in pathways which also code luminance information.
对一组18名多发性硬化症患者进行了对比敏感度和色觉测量。在5个空间频率和4个时间频率下测量的对比敏感度损失，在11名患者中被发现具有显著性。15名患者的红/绿（瑞利方程）和绿/蓝（恩格尔金-特伦德伦堡方程）皮克福德-尼科尔森色盲检查镜设置异常。将20种时空损失中的每一种与色觉损失进行关联，发现在19种情况下，红/绿损失大于绿/蓝损失。绿/蓝损失与时空损失均无显著相关性，而在2至8周/度之间，11/12种时空情况与红/绿颜色损失显示出显著相关性。这些结果支持在视觉通路中皮质之前的一个阶段存在损伤位点，在该阶段红/绿颜色信息可能在编码亮度信息的通路中被编码。
