运动期间使用近红外光谱测量的骨骼肌组织饱和度变化与闭塞后反应性充血相关。
Skeletal Muscle Tissue Saturation Changes Measured Using Near Infrared Spectroscopy During Exercise Are Associated With Post-Occlusive Reactive Hyperaemia.
作者信息
Jones Siana, Tillin Therese, Williams Suzanne, Rapala Alicja, Chaturvedi Nishi, Hughes Alun D
机构信息
MRC Unit for Lifelong Health & Ageing at UCL, Department of Population Science and Experimental Medicine, Institute for Cardiovascular Science, University College London, London, United Kingdom.
出版信息
Front Physiol. 2022 Jul 8;13:919754. doi: 10.3389/fphys.2022.919754. eCollection 2022.
Measuring local haemodynamics in skeletal muscle has the potential to provide valuable insight into the oxygen delivery to tissue, especially during high demand situations such as exercise. The aim of this study was to compare the skeletal muscle microvascular response during post-occlusive reactive hyperaemia (PORH) with the response to exercise, each measured using near-infrared spectroscopy (NIRS) and to establish if associations exist between muscle measures and exercise capacity or sex. Participants were from a population-based cohort study, the Southall and Brent Revisited (SABRE) study. Skeletal muscle measures included changes in tissue saturation index at the onset of exercise (∆TSI) and across the whole of exercise (∆TSI), time to 50%, 95% and 100% PORH, rate of PORH recovery, area under the curve (AUC) and total oxygenated Haemoglobin (oxy-Hb) change during PORH. Exercise capacity was measured using a 6-min stepper test (6MST). Analysis was by multiple linear regression. In total, 558 participants completed the 6MST with NIRS measures of TSI (mean age±SD: 73 ± 7years, 59% male). A sub-set of 149 participants also undertook the arterial occlusion. Time to 100% PORH, recovery rate, AUC and ∆oxy-Hb were all associated with ∆TSI (β-coefficient (95%CI): 0.05 (0.01, 0.09), = 0.012; -47 (-85, -9.9), = 0.014; 1.7 (0.62, 2.8), = 0.002; 0.04 (0.002.0.108), = 0.041, respectively). Time to 95% & 100% PORH, AUC and ∆oxy-Hb were all associated with ∆TSI (β-coefficient (95%CI): -0.07 (-0.12,-0.02), = 0.02; -0.03 (-0.05, -0.003), = 0.028; 0.85 (0.18, 1.5), = 0.013 & 0.05 (0.02, 0.09), = 0.001, respectively). AUC and ∆Oxy-Hb were associated with steps achieved (β-coefficient (95%CI): 18.0 (2.3, 33.7), = 0.025; 0.86 (0.10, 1.6), = 0.027). ∆TSI was associated with steps and highest VO (1.7 (0.49, 2.9), = 0.006; 7.7 (3.2, 12.3), = 0.001). ∆TSI was associated with steps and VO but this difference was attenuated towards the null after adjustment for age, sex and ethnicity. ∆TSI was greater in women (3.4 (0.4, 8.9) versus 2.1 (0.3, 7.4), = 0.017) and ∆TSI was lower in women versus men (2.4 (0.2, 10.2) versus 3.2 (0.2, 18.2), = 0.016). These Local microvascular NIRS-measures are associated with exercise capacity in older adults and several measures can detect differences in microvascular reactivity between a community-based sample of men and women.
测量骨骼肌局部血流动力学有可能为了解组织的氧气输送情况提供有价值的见解，尤其是在运动等高需求情况下。本研究的目的是比较闭塞后反应性充血（PORH）期间骨骼肌微血管反应与运动反应，二者均使用近红外光谱（NIRS）进行测量，并确定肌肉测量值与运动能力或性别之间是否存在关联。参与者来自一项基于人群的队列研究，即绍索尔和布伦特再研究（SABRE）。骨骼肌测量指标包括运动开始时（∆TSI）和整个运动过程中（∆TSI）的组织饱和度指数变化、达到50%、95%和100%PORH的时间、PORH恢复率、曲线下面积（AUC）以及PORH期间总氧合血红蛋白（oxy-Hb）变化。使用6分钟踏阶试验（6MST）测量运动能力。通过多元线性回归进行分析。共有558名参与者完成了6MST并进行了TSI的NIRS测量（平均年龄±标准差：73±7岁，59%为男性）。149名参与者的一个子集还进行了动脉闭塞。达到100%PORH的时间、恢复率、AUC和∆oxy-Hb均与∆TSI相关（β系数（95%置信区间）：0.05（0.01，0.09），P = 0.012；-47（-85，-9.9），P = 0.014；1.7（0.62，2.8），P = 0.002；0.04（0.002，0.108），P = 0.041）。达到95%和100%PORH的时间、AUC和∆oxy-Hb均与∆TSI相关（β系数（95%置信区间）：-0.07（-0.12，-0.02），P = 0.02；-0.03（-0.05，-0.003），P = 0.028；0.85（0.18，1.5），P = 0.013和0.05（0.02，0.09），P = 0.001）。AUC和∆Oxy-Hb与完成的步数相关（β系数（95%置信区间）：18.0（2.3，33.7），P = 0.025；0.86（0.10，1.6），P = 0.027）。∆TSI与步数和最高摄氧量相关（1.7（0.49，2.9），P = 0.006；7.7（3.2，12.3），P = 0.001）。∆TSI与步数和摄氧量相关，但在调整年龄、性别和种族后，这种差异向零值减弱。女性的∆TSI更大（3.4（0.4，8.9）对2.1（0.3，7.4），P = 0.017），且女性的∆TSI低于男性（2.4（0.2，10.2）对3.2（0.2，18.2），P = 0.016）。这些局部微血管NIRS测量值与老年人的运动能力相关，并且有几项测量可以检测出基于社区的男性和女性样本之间微血管反应性的差异。
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