Papanicolaou N, Hatziantoniou C, Dontas A, Gkikas E L, Paris M, Gkikas G, Bariety J
Nephron. 1987;45(4):277-82. doi: 10.1159/000184163.
Glycerol-treated rats exhibited significantly increased urinary thromboxane B2(TXB)2, prostaglandin E2 (PGE2) and 6-ketoprostaglandin F1 alpha (6kPGF1 alpha) excretion and urine volume (UV). These increases were associated with significant decreases in creatinine clearance (CCr), urinary sodium concentration (UNa), urinary sodium excretion (UNaV), and fractional excretion of sodium (FENa%), which is consistent with the development of the prerenal (reversible) phase of acute renal failure (ARF). When glycerol-treated rats were pretreated with a selective inhibitor of thromboxane A2 (TXA2) synthesis (imidazole), urinary PGE2 and 6kPGF1 alpha excretion and UV remained unchanged, whereas CCr, UNa, UNaV decreases were partially prevented. Additionally, FENa% was increased, indicating inhibition of sodium reabsorption. The findings indicate that inhibition of TXA2 synthesis increases UNaV and partially improves CCr in glycerol-treated rats. Further histologic observation and functional follow-up over longer periods of time are needed to clarify the role of TXA2 in the development of ARF.
经甘油处理的大鼠尿中血栓素B2（TXB）2、前列腺素E2（PGE2）和6-酮-前列腺素F1α（6kPGF1α）排泄量及尿量（UV）显著增加。这些增加与肌酐清除率（CCr）、尿钠浓度（UNa）、尿钠排泄量（UNaV）及钠排泄分数（FENa%）显著降低相关，这与急性肾衰竭（ARF）肾前性（可逆）期的发展一致。当用血栓素A2（TXA2）合成的选择性抑制剂（咪唑）预处理经甘油处理的大鼠时，尿PGE2和6kPGF1α排泄量及UV保持不变，而CCr、UNa、UNaV的降低得到部分预防。此外，FENa%增加，表明钠重吸收受到抑制。这些发现表明，抑制TXA2合成可增加UNaV，并部分改善经甘油处理大鼠的CCr。需要进一步的组织学观察和更长时间的功能随访，以阐明TXA2在ARF发展中的作用。
