Hatziantoniou C, Papanikolaou N
Experientia. 1986 Jun 15;42(6):613-5. doi: 10.1007/BF01955558.
Acute renal failure (ARF) was associated with increased urinary thromboxane (TXA2) excretion and lessened excretion of sodium (UNaV) and fractional excretion of sodium (FENa%). The inhibitor of thromboxane A2-synthetase OKY-046 enhanced sodium excretion and fractional excretion of sodium in normal and saline loaded animals whereas it partially prevented the reduction in sodium excretion and creatinine clearance and significantly increased fractional excretion of sodium in glycerol treated rats suggesting a partial protection against the development of acute renal failure.
急性肾衰竭（ARF）与尿血栓素（TXA2）排泄增加以及钠排泄量（UNaV）和钠分数排泄率（FENa%）降低有关。血栓素A2合成酶抑制剂OKY - 046可增加正常动物和生理盐水负荷动物的钠排泄及钠分数排泄率，而在甘油处理的大鼠中，它可部分阻止钠排泄和肌酐清除率的降低，并显著增加钠分数排泄率，提示对急性肾衰竭的发生有部分保护作用。
