Abdulmassih Z, Duverlie G, Morinière P, Atik A, Hannoun C, Henrotte J G, Daniel P, Fournier A
Nephrologie. 1987;8(1):23-6.
Humoral response to influenza vaccination being variable in uremic patients and being negatively correlated to red blood cell magnesium (RBC Mg) in non-uremic subjects, RBC Mg as well as plasma concentration of Mg were measured simultaneously with the antibodies titers after 1 and 2 injections of influenza vaccine in 21 non-uremic subjects and 47 patients on chronic hemodialysis. The RBC Mg and plasma Mg (MgP) were significantly higher in the dialysed patients (74 +/- 12 mg/l; 25 +/- 8 mg/l) than in the non-uremic subjects (54 +/- 5 mg/l; 19.4 +/- 1.5 mg/l). Furthermore, in the uremics RBC Mg was correlated to PMg whereas such a correlation was absent in the non-uremic patients. The humoral response of the uremic patients is depressed and becomes comparable to that of the non-uremic subjects after 1 injection only after 2 injections. In the uremic patients, the depressed humoral response is associated with higher RBC Mg (greater than 70 mg/l). The humoral response to influenza vaccine is depressed in uremic patients who have either the HBs antigen or no response to the hepatitis B vaccine but no link has been found between this immune status against the hepatitis B and RBC Mg. In conclusion, the humoral response of the uremic patients to influenza vaccine is depressed so that a second injection is necessary to give them sufficient protection.
尿毒症患者对流感疫苗的体液反应存在差异，且在非尿毒症患者中与红细胞镁（RBC Mg）呈负相关。在21名非尿毒症受试者和47名接受慢性血液透析的患者中，在注射1剂和2剂流感疫苗后，同时测量RBC Mg以及镁的血浆浓度和抗体滴度。透析患者的RBC Mg和血浆镁（MgP）水平（74±12 mg/l；25±8 mg/l）显著高于非尿毒症受试者（54±5 mg/l；19.4±1.5 mg/l）。此外，在尿毒症患者中，RBC Mg与PMg相关，而在非尿毒症患者中不存在这种相关性。尿毒症患者的体液反应受到抑制，仅在注射2剂后，其体液反应才与非尿毒症受试者相当。在尿毒症患者中，体液反应受到抑制与较高的RBC Mg（大于70 mg/l）有关。对乙肝抗原呈阳性或对乙肝疫苗无反应的尿毒症患者对流感疫苗的体液反应受到抑制，但未发现这种乙肝免疫状态与RBC Mg之间存在关联。总之，尿毒症患者对流感疫苗的体液反应受到抑制，因此需要注射第二剂以给予他们足够的保护。
