Li Weiwei, Zhang Lin, Jing Yuanming, Yang Yanfei, Wang Yulong
Department of Gastroenterology, Shaoxing People's Hospital, Shaoxing, China.
Department of Clinical Pharmacy, Shaoxing People's Hospital, Shaoxing, China.
Front Oncol. 2022 Jul 6;12:889417. doi: 10.3389/fonc.2022.889417. eCollection 2022.
It remains unknown whether gastric histopathology is associated with the occurrence of colonic neoplasms. We aimed to clarify the association between gastric histopathology and different types of colorectal polyps (CP) and colorectal cancer (CRC), and whether various gastric histopathologies are risk factors for different types of CP and CRC.
A retrospective cross-sectional study was conducted on 5,986 patients who underwent gastroscopy and colonoscopy simultaneously at Shaoxing People's Hospital from August 1, 2019, to May 31, 2020. The Pearson χ test was used to analyze the occurrence of various gastric histopathologies in different types of CP and CRC, and logistic regression was used to determine whether various gastric histopathologies were risk factors for different types of CP and CRC.
For the Chinese population, male sex (odds ratio [OR] 1.67, 95% confidence interval [CI] 1.41-1.97, < 0.001) and old age (OR 1.03, 95% CI 1.02-1.04, < 0.001) were risk factors for non-adenomatous polyps (NAP), but () and various gastric histopathologies were not significant in the NAP compared with the normal group. Nevertheless, it is noteworthy that, similar to male sex and old age, (OR 1.22, 95% CI 1.08-1.38, 0.002), low-grade intraepithelial neoplasia (LGIN) (OR 1.79, 95% CI 1.21-2.66, 0.004), gastric fundus gland polyps (FGPs) (OR 1.44, 95% CI 1.11-1.87, 0.007), hyperplastic/inflammatory gastric polyps (GHP or GIP) (OR 1.50, 95% CI 1.06-2.12, 0.022), and atrophy/intestinal metaplasia (AG or IM) (OR 1.27, 95% CI 1.13-1.43, < 0.001) were all risk factors for colorectal adenomatous polyps (AP). However, the results of CRC showed that old age (OR 1.13, 95% CI 1.10-1.16, < 0.001) and (OR 1.67, 95% CI 0.99-2.75, < 0.05) were risk factors for CRC (OR 1.67, 95% CI 0.99-2.75, < 0.05), but not sex and various gastric histopathologies ( > 0.05).
Gastric histopathology, such as AG or IM, LGIN, FGP, and GHP or GIP, were risk factors for AP, but not for NAP and CRC, indicating that gastric histopathology has potential predictive value for AP in the Chinese population.
胃组织病理学与结肠肿瘤的发生是否相关尚不清楚。我们旨在阐明胃组织病理学与不同类型的大肠息肉（CP）和结直肠癌（CRC）之间的关联，以及各种胃组织病理学是否是不同类型CP和CRC的危险因素。
对2019年8月1日至2020年5月31日在绍兴市人民医院同时接受胃镜和结肠镜检查的5986例患者进行回顾性横断面研究。采用Pearson χ检验分析不同类型CP和CRC中各种胃组织病理学的发生情况，并采用逻辑回归分析确定各种胃组织病理学是否是不同类型CP和CRC的危险因素。
对于中国人群，男性（优势比[OR]1.67，95%置信区间[CI]1.41 - 1.97，P < 0.001）和老年（OR 1.03，95% CI 1.02 - 1.04，P < 0.001）是非腺瘤性息肉（NAP）的危险因素，但（此处原文缺失信息）以及与正常组相比，各种胃组织病理学在NAP中无显著差异。然而，值得注意的是，与男性和老年相似，（此处原文缺失信息）（OR 1.22，95% CI 1.08 - 1.38，P = 0.002）、低级别上皮内瘤变（LGIN）（OR 1.79，95% CI 1.21 - 2.66，P = 0.004）、胃底腺息肉（FGP）（OR 1.44，95% CI 1.11 - 1.87，P = 0.007）、增生性/炎性胃息肉（GHP或GIP）（OR 1.50，95% CI 1.06 - 2.12，P = 0.022）以及萎缩/肠化生（AG或IM）（OR 1.27，95% CI 1.13 - 1.43，P < 0.001）均是大肠腺瘤性息肉（AP）的危险因素。然而，CRC的结果显示，老年（OR 1.13，95% CI 1.10 - 1.
