Menon M K, Kodama C K, Cummins J T, Von Hungen K
Neuropharmacology. 1987 Feb-Mar;26(2-3):247-53. doi: 10.1016/0028-3908(87)90215-2.
Amfonelic acid (AFA), a non-amphetamine central stimulant dose-dependently reduced the hypnotic effect of ethanol in C57B1/6 mice. It did not enhance the elimination of ethanol. Amfonelic acid failed to modify the duration of pentobarbitone-induced hypnosis or the ethanol-induced hypothermia in these animals. Combined treatment with amfonelic acid and a lipophilic alpha 1-adrenoceptor agonist was not more effective than amfonelic acid alone in blocking ethanol hypnosis. The stimulation of locomotor activity by amfonelic acid in C57B1/6 mice was more sensitive to the blocking effect of ethanol than stimulation induced by d-amphetamine. The blocking effect of amfonelic acid, but not that of d-amphetamine, on the effects of ethanol developed tolerance. In pimozide-pretreated mice, amfonelic acid failed to reduce the ethanol-induced hypnosis. Hence it appears that dopamine (DA) released by amfonelic acid is responsible for its antagonism of ethanol. However, though amfonelic acid acted as a strong releaser of DA in Swiss-Webster, CD-1, DBA-2 and BALB/c mice, in these strains it failed to reduce the effect of ethanol. Moreover, methylphenidate, a dopaminergic stimulant, which acts by a mechanism similar to that of amfonelic acid was not effective in reducing the hypnotic effect of ethanol in C57B1/6 mice. For these reasons, additional mechanisms may have to be considered to explain this strain-dependent effect of amfonelic acid.
安福芬酸（AFA）是一种非苯丙胺类中枢兴奋剂，能剂量依赖性地降低C57B1/6小鼠体内乙醇的催眠作用。它不会增强乙醇的消除。安福芬酸未能改变这些动物中戊巴比妥诱导的催眠持续时间或乙醇诱导的体温过低。在阻断乙醇催眠方面，安福芬酸与亲脂性α1 - 肾上腺素能受体激动剂联合治疗并不比单独使用安福芬酸更有效。在C57B1/6小鼠中，安福芬酸对运动活性的刺激比右旋苯丙胺诱导的刺激对乙醇的阻断作用更敏感。安福芬酸对乙醇作用的阻断效应，而非右旋苯丙胺的阻断效应，产生了耐受性。在匹莫齐特预处理的小鼠中，安福芬酸未能降低乙醇诱导的催眠作用。因此，似乎安福芬酸释放的多巴胺（DA）是其拮抗乙醇作用的原因。然而，尽管安福芬酸在瑞士韦伯斯特、CD - 1、DBA - 2和BALB/c小鼠中是一种强效的DA释放剂，但在这些品系中它未能降低乙醇的作用。此外，哌醋甲酯是一种多巴胺能兴奋剂，其作用机制与安福芬酸类似，但在降低C57B1/6小鼠体内乙醇的催眠作用方面无效。基于这些原因，可能必须考虑其他机制来解释安福芬酸这种品系依赖性效应。
