Haghighi S S, Chehrazi B B, Higgins R S, Remington W J, Wagner F C
Neurosurgery. 1987 Apr;20(4):536-41. doi: 10.1227/00006123-198704000-00005.
The effect of continuous infusion of lidocaine on acute spinal cord trauma in cats was studied. Intravenous and subarachnoid administration of lidocaine did not alter generation and conduction of the spinal evoked responses (SERs) in intact animals. The cortical somatosensory evoked responses and SERs were abolished after weight drop injuries of 120 and 400 g-cm. No return of the evoked responses occurred within 4 hours after trauma in either the lidocaine- or the saline-treated groups. Loss of SERs and appearance of an evoked injury potential were sensitive determinants of spinal cord injury. We concluded that lidocaine treatment did not facilitate the return of spinal cord function in this model of acute spinal cord injury.
研究了持续输注利多卡因对猫急性脊髓损伤的影响。在完整动物中，静脉内和蛛网膜下腔给予利多卡因不会改变脊髓诱发反应（SERs）的产生和传导。在120和400克 - 厘米的重物坠落损伤后，皮质体感诱发反应和SERs消失。在利多卡因治疗组或生理盐水治疗组中，创伤后4小时内诱发反应均未恢复。SERs的丧失和诱发损伤电位的出现是脊髓损伤的敏感决定因素。我们得出结论，在这种急性脊髓损伤模型中，利多卡因治疗并不能促进脊髓功能的恢复。
