Evans D E, Kobrine A I
Neurosurgery. 1987 Apr;20(4):542-7. doi: 10.1227/00006123-198704000-00006.
Previous animal studies in our laboratory revealed that acute cerebral ischemia induced by air embolism is accompanied by a sharp and pronounced rise in both systemic blood pressure and intracranial pressure. To investigate possible approaches to the treatment of severe intracranial hypertension, we produced cerebral air embolism in anesthetized, ventilated cats by the infusion of air into the vertebral artery. Untreated animals consistently experienced severe acute intracranial hypertension. Pretreating the animals with lidocaine greatly attenuated the intracranial hypertension caused by air embolism. Lidocaine given after the injury was also effective in reducing intracranial pressure. Our results suggest that lidocaine may be a useful agent for reducing intracranial hypertension associated with ischemic or traumatic injuries to the brain.
我们实验室之前的动物研究表明，空气栓塞诱发的急性脑缺血会伴随着全身血压和颅内压急剧显著升高。为了研究治疗严重颅内高压的可能方法，我们通过向椎动脉注入空气，在麻醉、通气的猫身上制造脑空气栓塞。未经治疗的动物始终会经历严重的急性颅内高压。用利多卡因预处理动物可大大减轻空气栓塞引起的颅内高压。损伤后给予利多卡因在降低颅内压方面也有效。我们的结果表明，利多卡因可能是一种用于降低与脑缺血或创伤性损伤相关的颅内高压的有用药物。
