Shang Tengda, Wang Kebing, Tang Shusheng, Shen Yang, Zhou Lei, Zhang Lu, Zhao Yuancong, Li Xin, Cai Lin, Wang Jin
School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, China.
Department of Cardiology, Third People's Hospital of Chengdu Affiliated to Southwest Jiaotong University, Chengdu, China.
Front Bioeng Biotechnol. 2022 Jul 7;10:940172. doi: 10.3389/fbioe.2022.940172. eCollection 2022.
Magnesium (Mg)-based materials are considered as potential materials for biodegradable vascular stents, and some Mg-based stents have obtained regulatory approval. However, the development and application of Mg-based stents are still restricted by the rapid degradation rate of Mg and its alloys. In order to screen out the desirable Mg-based materials for stents, the degradation behavior still needs further systematic study, especially the degradation behavior under the action of near-physiological fluid. Currently, the commonly used Mg-based vascular stent materials include pure Mg, AZ31, and WE43. In this study, we systematically evaluated their corrosion behaviors in a dynamic environment and studied the effect of their degradation products on the behavior of vascular cells. The results revealed that the corrosion rate of different Mg-based materials was related to the composition of the elements. The dynamic environment accelerated the corrosion of Mg-based materials. All the same, AZ31 still shows good corrosion resistance. The effect of corrosive products on vascular cells was beneficial to re-endothelialization and inhibition of smooth muscle cell proliferation at the implantation site of vascular stent materials.
镁（Mg）基材料被认为是可生物降解血管支架的潜在材料，一些镁基支架已获得监管批准。然而，镁基支架的开发和应用仍然受到镁及其合金快速降解速率的限制。为了筛选出理想的镁基支架材料，其降解行为仍需进一步系统研究，尤其是在近生理流体作用下的降解行为。目前，常用的镁基血管支架材料包括纯镁、AZ31和WE43。在本研究中，我们系统地评估了它们在动态环境中的腐蚀行为，并研究了其降解产物对血管细胞行为的影响。结果表明，不同镁基材料的腐蚀速率与元素组成有关。动态环境加速了镁基材料的腐蚀。尽管如此，AZ31仍表现出良好的耐腐蚀性。腐蚀产物对血管细胞的作用有利于血管支架材料植入部位的再内皮化和平滑肌细胞增殖的抑制。
