用吲哚洛尔进行一或两剂的抗高血压治疗。一项对比试验。

Antihypertensive treatment with pindolol in one or two doses. A comparative trial.

作者信息

Gyntelberg F, Rasmussen K, Harvald B

出版信息

Acta Med Scand. 1978;204(3):169-71. doi: 10.1111/j.0954-6820.1978.tb08419.x.

DOI:10.1111/j.0954-6820.1978.tb08419.x

Abstract

A comparative trial was carried out in 21 patients on the antihypertensive effect of pindolol given once or twice a day. A change-over design was employed, with two treatment schedules and four treamtnet periods of six weeks each. No statistically significant difference was found in BP lowering effect between one and two daily doses. It is unlikely that a switch from pindolol twice daily to the same amount once daily will crease the BP by more than at most 1.0 mmHg systolic and 2.2 mmHg diastolic, or decrease it by more than 2.7 and 1.0 mmHg, respectively. It is concluded that pindolol given once daily can be recommended.

摘要

对21例患者进行了一项比较试验，以研究每日服用一次或两次吲哚洛尔的降压效果。采用了交叉设计，有两种治疗方案，每个治疗阶段为期六周，共四个治疗阶段。每日一次剂量和每日两次剂量的降压效果在统计学上无显著差异。从每日两次服用吲哚洛尔改为相同剂量每日一次服用，收缩压升高最多不会超过1.0 mmHg，舒张压升高最多不会超过2.2 mmHg，或者收缩压降低最多不会超过2.7 mmHg，舒张压降低最多不会超过1.0 mmHg。结论是可以推荐每日服用一次吲哚洛尔。