Frithz G
Acta Med Scand Suppl. 1977;606:77-81. doi: 10.1111/j.0954-6820.1977.tb18033.x.
Two studies are presented on the possibility of treating hypertension with pindolol once daily. In the first one, patients already treated with multiple doses of pindolol, propranolol or alprenolol were shifted to single dose regime with pindolol, given in the morning. In most cases an adequate blood pressure control could be maintained on a dose of up to 20 mg pindolol. In the other study, previously untreated patients with mild to moderate hypertension were treated from the beginning with a single dose of pindolol. An adequate pressure control was also obtained in most of these patients with a dose not surpassing 20 mg pindolol once daily. In non-responders, the addition of a once daily dose of a diuretic resulted in an adequate pressure control. In both studies side-effects were few. The absence of sleep disturbances and beta-blocker induced bradycardia was particularly noteworthy.
有两项关于每日服用一次吲哚洛尔治疗高血压可能性的研究。在第一项研究中，已接受多剂量吲哚洛尔、普萘洛尔或阿普洛尔治疗的患者改为早晨服用单剂量吲哚洛尔。在大多数情况下，服用高达20毫克吲哚洛尔的剂量可维持足够的血压控制。在另一项研究中，先前未治疗的轻度至中度高血压患者从一开始就用单剂量吲哚洛尔治疗。这些患者中的大多数每日服用不超过20毫克吲哚洛尔的剂量也能获得足够的血压控制。对于无反应者，每日加用一次利尿剂可实现足够的血压控制。两项研究中的副作用都很少。尤其值得注意的是没有睡眠障碍和β受体阻滞剂引起的心动过缓。
